Abstract
Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.
Original language | English |
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Pages (from-to) | 5753-5758 |
Number of pages | 6 |
Journal | Current Pharmaceutical Design |
Volume | 18 |
Issue number | 35 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Auto-immunity
- Genetic gluten intolerance
- Intestinal anti-transglutaminase antibodies
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology