Gluten-dependent intestinal autoimmune response

Ilma Rita Korponay-Szabó, Zsófia Simon-Vecsei, Luigina de Leo, Tarcisio Not

Research output: Contribution to journalArticlepeer-review

Abstract

Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.

Original languageEnglish
Pages (from-to)5753-5758
Number of pages6
JournalCurrent Pharmaceutical Design
Volume18
Issue number35
DOIs
Publication statusPublished - 2012

Keywords

  • Auto-immunity
  • Genetic gluten intolerance
  • Intestinal anti-transglutaminase antibodies

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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