Gluten-sensitive enteropathy in dermatitis herpetiformis: A freeze-fracture and morphometric study of the jejunal mucosa after one and two years of gluten-free diet

G. Gasparini, A. Brezzi, M. Barbareschi, D. Bauer, E. Fogato, L. Matturri, M. Vecchi, M. Landoni, R. Franchis

Research output: Contribution to journalArticle

Abstract

The authors report and discuss the results obtained by means of the combinations of the freeze-fracture technique with morphometric analysis in the investigation of the healing processes of gluten-sensitive enteropathy in dermatitis herpetiformis (DH) patients after one and two years of gluten-free diet (GFD). The samples of jejunal mucosa of 4 patients showed after the first year of GFD microvilli recover to their normal structure, but their number remain low, while during the second year we noted a striking increase in their number too. On the contrary, the tight-junctions net is reconstructed in a relatively short time, and recovers its normal appearance within one year of GFD.

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume132
Issue number1
Publication statusPublished - 1997

    Fingerprint

Keywords

  • celiac disease, diet therapy
  • celiac disease, pathology
  • dermatitis herpetiforms

ASJC Scopus subject areas

  • Dermatology

Cite this