Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study.

Marcella Malavolti, Carlotta Malagoli, Catherine M. Crespi, Furio Brighenti, Claudia Agnoli, Sabina Sieri, Vittorio Krogh, Chiara Fiorentini, Francesca Farnetani, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Anna Lanzoni, Leonardo Veneziano, Annarosa Virgili, Calogero Pagliarello, Claudio Feliciani, Pier Alessandro Fanti, Emi Dika, Giovanni PellacaniMarco Vinceti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.
Original languageUndefined/Unknown
Pages (from-to)432-438
Number of pages7
JournalBritish Journal of Nutrition
Volume117
Issue number3
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Case-control studies, CI confidence interval, EPIC European Prospective Investigation into Cancer and Nutrition, Epidemiology, FFQ food frequency questionnaire, GI glycaemic index, GL glycaemic load, Glycaemic index, Glycaemic load, melanoma, OR odds ratio, SFA saturated fatty acids

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Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study. / Malavolti, Marcella; Malagoli, Carlotta; Crespi, Catherine M.; Brighenti, Furio; Agnoli, Claudia; Sieri, Sabina; Krogh, Vittorio; Fiorentini, Chiara; Farnetani, Francesca; Longo, Caterina; Ricci, Cinzia; Albertini, Giuseppe; Lanzoni, Anna; Veneziano, Leonardo; Virgili, Annarosa; Pagliarello, Calogero; Feliciani, Claudio; Fanti, Pier Alessandro; Dika, Emi; Pellacani, Giovanni; Vinceti, Marco.

In: British Journal of Nutrition, Vol. 117, No. 3, 01.02.2017, p. 432-438.

Research output: Contribution to journalArticle

Malavolti, M, Malagoli, C, Crespi, CM, Brighenti, F, Agnoli, C, Sieri, S, Krogh, V, Fiorentini, C, Farnetani, F, Longo, C, Ricci, C, Albertini, G, Lanzoni, A, Veneziano, L, Virgili, A, Pagliarello, C, Feliciani, C, Fanti, PA, Dika, E, Pellacani, G & Vinceti, M 2017, 'Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study.', British Journal of Nutrition, vol. 117, no. 3, pp. 432-438. https://doi.org/10.1017/S000711451700006X
Malavolti, Marcella ; Malagoli, Carlotta ; Crespi, Catherine M. ; Brighenti, Furio ; Agnoli, Claudia ; Sieri, Sabina ; Krogh, Vittorio ; Fiorentini, Chiara ; Farnetani, Francesca ; Longo, Caterina ; Ricci, Cinzia ; Albertini, Giuseppe ; Lanzoni, Anna ; Veneziano, Leonardo ; Virgili, Annarosa ; Pagliarello, Calogero ; Feliciani, Claudio ; Fanti, Pier Alessandro ; Dika, Emi ; Pellacani, Giovanni ; Vinceti, Marco. / Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study. In: British Journal of Nutrition. 2017 ; Vol. 117, No. 3. pp. 432-438.
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abstract = "Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 {\%} CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.",
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T1 - Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study.

AU - Malavolti, Marcella

AU - Malagoli, Carlotta

AU - Crespi, Catherine M.

AU - Brighenti, Furio

AU - Agnoli, Claudia

AU - Sieri, Sabina

AU - Krogh, Vittorio

AU - Fiorentini, Chiara

AU - Farnetani, Francesca

AU - Longo, Caterina

AU - Ricci, Cinzia

AU - Albertini, Giuseppe

AU - Lanzoni, Anna

AU - Veneziano, Leonardo

AU - Virgili, Annarosa

AU - Pagliarello, Calogero

AU - Feliciani, Claudio

AU - Fanti, Pier Alessandro

AU - Dika, Emi

AU - Pellacani, Giovanni

AU - Vinceti, Marco

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

AB - Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

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JO - British Journal of Nutrition

JF - British Journal of Nutrition

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