Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study.

Marcella Malavolti, Carlotta Malagoli, Catherine M. Crespi, Furio Brighenti, Claudia Agnoli, Sabina Sieri, Vittorio Krogh, Chiara Fiorentini, Francesca Farnetani, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Anna Lanzoni, Leonardo Veneziano, Annarosa Virgili, Calogero Pagliarello, Claudio Feliciani, Pier Alessandro Fanti, Emi Dika, Giovanni PellacaniMarco Vinceti

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Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.
Original languageUndefined/Unknown
Pages (from-to)432-438
Number of pages7
JournalBritish Journal of Nutrition
Issue number3
Publication statusPublished - Feb 1 2017


  • Case-control studies, CI confidence interval, EPIC European Prospective Investigation into Cancer and Nutrition, Epidemiology, FFQ food frequency questionnaire, GI glycaemic index, GL glycaemic load, Glycaemic index, Glycaemic load, melanoma, OR odds ratio, SFA saturated fatty acids

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