Abstract
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 432-438 |
| Number of pages | 7 |
| Journal | British Journal of Nutrition |
| Volume | 117 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
Keywords
- Case-control studies, CI confidence interval, EPIC European Prospective Investigation into Cancer and Nutrition, Epidemiology, FFQ food frequency questionnaire, GI glycaemic index, GL glycaemic load, Glycaemic index, Glycaemic load, melanoma, OR odds ratio, SFA saturated fatty acids
Cite this
Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study. / Malavolti, Marcella; Malagoli, Carlotta; Crespi, Catherine M.; Brighenti, Furio; Agnoli, Claudia; Sieri, Sabina; Krogh, Vittorio; Fiorentini, Chiara; Farnetani, Francesca; Longo, Caterina; Ricci, Cinzia; Albertini, Giuseppe; Lanzoni, Anna; Veneziano, Leonardo; Virgili, Annarosa; Pagliarello, Calogero; Feliciani, Claudio; Fanti, Pier Alessandro; Dika, Emi; Pellacani, Giovanni; Vinceti, Marco.
In: British Journal of Nutrition, Vol. 117, No. 3, 01.02.2017, p. 432-438.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case-control study.
AU - Malavolti, Marcella
AU - Malagoli, Carlotta
AU - Crespi, Catherine M.
AU - Brighenti, Furio
AU - Agnoli, Claudia
AU - Sieri, Sabina
AU - Krogh, Vittorio
AU - Fiorentini, Chiara
AU - Farnetani, Francesca
AU - Longo, Caterina
AU - Ricci, Cinzia
AU - Albertini, Giuseppe
AU - Lanzoni, Anna
AU - Veneziano, Leonardo
AU - Virgili, Annarosa
AU - Pagliarello, Calogero
AU - Feliciani, Claudio
AU - Fanti, Pier Alessandro
AU - Dika, Emi
AU - Pellacani, Giovanni
AU - Vinceti, Marco
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.
AB - Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2.38; 95 % CI 1.25, 4.52 for the highest v. the lowest quintile of GL score, P for trend 0.070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.
KW - Case-control studies, CI confidence interval, EPIC European Prospective Investigation into Cancer and Nutrition, Epidemiology, FFQ food frequency questionnaire, GI glycaemic index, GL glycaemic load, Glycaemic index, Glycaemic load, melanoma, OR odds rati
U2 - 10.1017/S000711451700006X
DO - 10.1017/S000711451700006X
M3 - Articolo
VL - 117
SP - 432
EP - 438
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 3
ER -