Glycemic index and glycemic load in endometrial cancer

Livia S A Augustin, Silvano Gallus, Cristina Bosetti, Fabio Levi, Eva Negri, Silvia Franceschi, Luigino Dal Maso, David J A Jenkins, Cyril W C Kendall, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Glycemic index (GI) and glycemic load (GL) are measures of the metabolic effects of dietary carbohydrates. The higher their value, the greater the glucose and insulin responses. Raised insulin levels are associated with endometrial cancer and with its risk factors including obesity, diabetes and hypertension. To study the role of the GI and GL we analyzed the data of two hospital-based case-control studies on endometrial cancer conducted between 1988-98 in Italy and Switzerland, including a total of 410 women with incident, histologically confirmed endometrial cancer and 753 controls admitted for acute, non-neoplastic diseases. A food frequency questionnaire was used to assess the subjects usual diet and to derive estimates of dietary GI and GL. The odds ratios (OR) of endometrial cancer, after adjustment for major risk factors, for the highest versus the lowest quintile of dietary GI and GL were 2.1 (95% confidence interval [CI] = 1.4-3.2) and 2.7 (95% CI = 1.8-4.2), respectively. The associations were stronger in older women, in those with higher body mass index and in hormone replacement therapy users. Our study supports the hypothesis of a direct association between GI and endometrial cancer risk.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - Jun 20 2003


  • Case-control
  • Endometrial cancer
  • Glycemic index
  • Glycemic load
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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