Glyceraldehyde-3-phosphate dehydrogenase is responsible for intranuclear localization of some oligonucleotides

V. Tomasi, P. P. Laktionov, A. V. Bryksin, N. V. Volod'ko, C. Griffoni, E. Y. Rykova, E. Spisni, R. Kraft, V. V. Vlassov

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear accumulation of ODNs has been associated with their binding to a series of nuclear proteins. These interactions could be responsible for the sequence-independent effects of ODNs as well as for their sequence-specific interactions and their intracellular distribution. Investigation of interaction of ODNs with these proteins may shed light on the mechanisms of cellular uptake and nuclear accumulation of oligonucleotides.

Original languageEnglish
Pages (from-to)863-867
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

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