Glycerol accelerates recovery of barrier function in vivo

Joachim W. Fluhr, M. Gloor, L. Lehmann, S. Lazzerini, F. Distante, E. Berardesca

Research output: Contribution to journalArticle

Abstract

Two studies were performed to evaluate the influence of glycerol on the recovery of damaged stratum corneum barrier function. Measurements of transepidermal water loss and capacitance were conducted in a 3-day follow-up after tape stripping (study 1) and a 7-day follow-up after a barrier damage due to a repeated washing with sodium lauryl sulphate. In study 1 a faster barrier repair (transepidermal water loss) was monitored in glycerol-treated sites. Significant differences between glycerol open vs. untreated and glycerol occluded vs. untreated were observed at day 3. Stratum corneum hydration showed significantly higher values in the sites treated with glycerol+occlusion, compared with all other sites. In study 2 a faster barrier repair was seen in glycerol-treated sites, with significant differences against untreated and base-treated sites 7 days after the end of the treatment. Stratum corneum hydration showed highest values in the glycerol treated sites after 3 days of treatment. Glycerol creates a stimulus for barrier repair and improves the stratum corneum hydration; stratum corneum hydration is not strictly related to barrier homeostasis and can be optimized by different mechanisms and pathways. The observed effects were based on the modulation of barrier repair and were not biased by the humectant effect of glycerol. As the glycerol-induced recovery of barrier function and stratum corneum hydration were observed even 7 days after the end of treatment, glycerol can be regarded as a barrier stabilizing and moisturizing compound.

Original languageEnglish
Pages (from-to)418-421
Number of pages4
JournalActa Dermato-Venereologica
Volume79
Issue number6
Publication statusPublished - 1999

Fingerprint

Recovery of Function
social stratum
Glycerol
Cornea
water
Recovery
Hygroscopic Agents
stimulus
damages
Water
Sodium Dodecyl Sulfate
Hydration
Homeostasis
Repair

Keywords

  • Barrier repair
  • Capacitance
  • Occlusion
  • SLS washing
  • Tape stripping
  • Transepidermal water loss (TEWL)

ASJC Scopus subject areas

  • Dermatology

Cite this

Fluhr, J. W., Gloor, M., Lehmann, L., Lazzerini, S., Distante, F., & Berardesca, E. (1999). Glycerol accelerates recovery of barrier function in vivo. Acta Dermato-Venereologica, 79(6), 418-421.

Glycerol accelerates recovery of barrier function in vivo. / Fluhr, Joachim W.; Gloor, M.; Lehmann, L.; Lazzerini, S.; Distante, F.; Berardesca, E.

In: Acta Dermato-Venereologica, Vol. 79, No. 6, 1999, p. 418-421.

Research output: Contribution to journalArticle

Fluhr, JW, Gloor, M, Lehmann, L, Lazzerini, S, Distante, F & Berardesca, E 1999, 'Glycerol accelerates recovery of barrier function in vivo', Acta Dermato-Venereologica, vol. 79, no. 6, pp. 418-421.
Fluhr JW, Gloor M, Lehmann L, Lazzerini S, Distante F, Berardesca E. Glycerol accelerates recovery of barrier function in vivo. Acta Dermato-Venereologica. 1999;79(6):418-421.
Fluhr, Joachim W. ; Gloor, M. ; Lehmann, L. ; Lazzerini, S. ; Distante, F. ; Berardesca, E. / Glycerol accelerates recovery of barrier function in vivo. In: Acta Dermato-Venereologica. 1999 ; Vol. 79, No. 6. pp. 418-421.
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