Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons

F. Nicoletti, P. L. Canonico

Research output: Contribution to journalArticle

Abstract

Glycine potentiates stimulation of inositol phospholipid hydrolysis by glutamate and N-methyl-D-aspartate, but not by quisqualate or carbamylcholine, in primary cultures of cerebellar granule cells. This potentiation occurs in the absence of extracellular Mg2+, but is more evident when stimulation of inositol phospholipid hydrolysis by N-methyl-D-aspartate is measured in the presence of 1 mM Mg2+. The action of glycine is not antagonized by strychnine. These results suggest that glycine acts as a positive modulator of signal transduction at a specific class of N-methyl-D-aspartate-sensitive glutamate receptors coupled to inositol phospholipid hydrolysis in cerebellar granule cells.

Original languageEnglish
Pages (from-to)724-727
Number of pages4
JournalJournal of Neurochemistry
Volume53
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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