Glycocalicin in the diagnosis and management of immune thrombocytopenia

A. Steffan, P. Predella, I. Cordiano, A. Girolami, L. De Marco, F. Fabris

Research output: Contribution to journalArticle

Abstract

We studied glycocalicin (GC), expressed as plasma GC concentration and as GC index (ratio to platelet count), in 129 thrombocytopenic patients (platelet count<100x109/l) and 60 sex- and age-matched controls. Seventy- two patients had idiopathic immune thrombocytopenia, 32 secondary immune thrombocytopenia, 8 microangiopathic thrombocytopenia and 17 thrombocytopenia secondary to bone marrow aplasia. Patients with immune thrombocytopenia (ITP) were also subclassified, according to their clinical behaviour, as having active disease or being in spontaneous or therapy-induced partial remission. A significant correlation was found between glycocalicin levels and platelet count both in normals and in patients with bone marrow aplasia (r = 0.75). ITP patients showed a GC index significantly higher than controls (6.02±7.87 vs. 0.9±0.2, p9/l) were studied, the mean level of GC and the GC index were significantly higher in those patients with active disease than in those in remission (0.97±0.38 vs. 0.58±0.17 μg/ml, p

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalEuropean Journal of Haematology
Volume61
Issue number2
Publication statusPublished - 1998

Keywords

  • Glycocalicin
  • Immune thrombocytopenia
  • Platelet

ASJC Scopus subject areas

  • Hematology

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    Steffan, A., Predella, P., Cordiano, I., Girolami, A., De Marco, L., & Fabris, F. (1998). Glycocalicin in the diagnosis and management of immune thrombocytopenia. European Journal of Haematology, 61(2), 77-83.