Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization

Matteo Piazza, Clara Rossini, Silvia Delia Fiorentina, Chiara Pozzi, Francesca Comelli, Isabella Bettoni, Paola Fusi, Barbara Costa, Francesco Peri

Research output: Contribution to journalArticle

Abstract

New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalJournal of Medicinal Chemistry
Volume52
Issue number4
DOIs
Publication statusPublished - Feb 26 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization'. Together they form a unique fingerprint.

Cite this