Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization

Matteo Piazza, Clara Rossini, Silvia Delia Fiorentina, Chiara Pozzi, Francesca Comelli, Isabella Bettoni, Paola Fusi, Barbara Costa, Francesco Peri

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

New glycolipids and a benzylammonium lipid were rationally designed by varying the chemical structure of a D-glucose-derived hit compound active as lipid A antagonist. We report the synthesis of these compounds, their in vitro activity as lipid A antagonists on HEK cells, and the capacity to inhibit LPS-induced septic shock in vivo. The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalJournal of Medicinal Chemistry
Volume52
Issue number4
DOIs
Publication statusPublished - Feb 26 2009

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Antisepsis
Lipid A
Glycolipids
Lipids
Septic Shock
Glucose
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Glycolipids and benzylammonium lipids as novel antisepsis agents : Synthesis and biological characterization. / Piazza, Matteo; Rossini, Clara; Fiorentina, Silvia Delia; Pozzi, Chiara; Comelli, Francesca; Bettoni, Isabella; Fusi, Paola; Costa, Barbara; Peri, Francesco.

In: Journal of Medicinal Chemistry, Vol. 52, No. 4, 26.02.2009, p. 1209-1213.

Research output: Contribution to journalArticle

Piazza, M, Rossini, C, Fiorentina, SD, Pozzi, C, Comelli, F, Bettoni, I, Fusi, P, Costa, B & Peri, F 2009, 'Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization', Journal of Medicinal Chemistry, vol. 52, no. 4, pp. 1209-1213. https://doi.org/10.1021/jm801333m
Piazza, Matteo ; Rossini, Clara ; Fiorentina, Silvia Delia ; Pozzi, Chiara ; Comelli, Francesca ; Bettoni, Isabella ; Fusi, Paola ; Costa, Barbara ; Peri, Francesco. / Glycolipids and benzylammonium lipids as novel antisepsis agents : Synthesis and biological characterization. In: Journal of Medicinal Chemistry. 2009 ; Vol. 52, No. 4. pp. 1209-1213.
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