Glycoprotein hormone α-subunit in pituitary adenomas

Paolo Beck-Peccoz, Luca Persani, Giovanni Faglia

Research output: Contribution to journalArticlepeer-review


Elevated serum glycoprotein hormone α-subunit (α-subunit) levels are seen in about one of six patients bearing pituitary adenomas. This finding has particular clinical significance in patients with nonfunctioning pituitary adenomas. Moreover, the measurement of α-subunit along with the calculation of the molar ratio between α-subunit and TSH, LH, or FSH is helpful in the diagnosis of glycoprotein hormone-secreting pituitary adenomas. Since serum α-subunit levels may vary greatly in several physiologic and pathologic conditions, care has to be taken to differentiate abnormal from normal states of α-subunit hypersecretion as well as to exclude causes of α-subunit overproduction only casually associated with the presence of pituitary tumors.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalTrends in Endocrinology and Metabolism
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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