Glycosaminoglycan therapy - A new approach to the prevention of recurrent urinary tract infections

Summary of presentations given at a satellite symposium at the 27th Annual European Association of Urology Congress, Paris, 24-28 February 2012

Pier Francesco Bassi, Rosanna Tarricone, Oriana Ciani, Massimo Lazzeri, Martin Romancik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Symptoms of recurrent urinary tract infections (UTIs) impact on a patient's quality of life and productivity, and the condition is therefore associated with wider health and economic implications. Eradication of the infection with prophylactic antibiotic treatment, as is the current management strategy, is associated with concerns including microbial resistance, the lack of new antimicrobial agent development and increasing costs for long-term treatment. The urothelium, the inner layer of the bladder wall, serves to protect the bladder from infection and the subsequent inflammatory cascade and focusing on restoring and maintaining the integrity of the urothelium is the basis of the new approach to treatingrecurrent UTIs. Intravesical instillation of a solution of hyaluronic acid and chondroitin sulphate (Ialuril®) in patients with recurrent UTIs was associated with fewer UTI recurrences, a longer time to recurrence and a greater improvement in quality of life than placebo treatment. Treatment with this intravesical formulation avoids the current concerns regarding antibiotic prophylaxis and may be a useful alternative prophylactic strategy for recurrent UTIs.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalEuropean Urological Review
Volume7
Issue number1
Publication statusPublished - 2012

Fingerprint

Paris
Glycosaminoglycans
Urinary Tract Infections
Urothelium
Urinary Bladder
Quality of Life
Intravesical Administration
Therapeutics
Recurrence
Antibiotic Prophylaxis
Chondroitin Sulfates
Hyaluronic Acid
Anti-Infective Agents
Infection
Placebos
Economics
Anti-Bacterial Agents
Costs and Cost Analysis
Health

Keywords

  • Chondroitin sulphate
  • Hylauronic acid
  • Intravesical
  • Sodium hyaluronate
  • Urinary tract infection

ASJC Scopus subject areas

  • Urology

Cite this

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