Glycosaminoglycans (GASs) in human cerebral tumors - Part 1. Biochemical findings

A. Bertolotto, M. T. Giordana, M. L. Magrassi, A. Mauro, D. Schiffer

Research output: Contribution to journalArticle

Abstract

GAG electrophoretic pattern and concentration have been studied in 38 human cerebral tumors and in specimens of normal nervous tissue. Gray matter had higher total GAG concentration and higher CA to HA ratio than white matter. In both, DS was present in very small amount whereas HS represented 15% of GAGs. All benign gliomas displayed the same electrophoretic pattern and contained more GAGs than normal nervous tissue. Dermatan sulfate was detected in malignant gliomas, as well as in other oncotypes, due to their mesodermic component. Ependymomas were particularly rich in HS and meningiomas were poor in HA.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalActa Neuropathologica
Volume58
Issue number2
DOIs
Publication statusPublished - Jun 1982

Keywords

  • Biochemistry
  • Cerebral tumours
  • Electrophoresis
  • Glycosaminoglycans

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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