Glycosyl phosphatidylinositol-anchored proteins and HIV infection

Massimo Alfano, Luca Cassetta, Guido Poli

Research output: Contribution to journalArticlepeer-review

Abstract

In addition to CD4 and chemokine receptors glycosyl phosphatidylinositol- anchored proteins (GPI-APs) have been involved in the regulation of the human immunodeficiency virus (HIV) life cycle. In this article we will review the mechanisms underlying the anti-HIV activities regulated by GPI-APs and their ligands. Understanding how GPI-APs finely regulate HIV infection and replication may unravel novel and complementary strategies to combat and control HIV infection.

Original languageEnglish
Pages (from-to)598-604
Number of pages7
JournalLetters in Drug Design and Discovery
Volume3
Issue number9
DOIs
Publication statusPublished - 2006

Keywords

  • GPI (Glycosyl Phosphatidylinositol)
  • GPI-AP (Glycosyl Phosphatidylinositol- Anchored Protein)
  • HIV (Human Immunodeficiency Virus)
  • PTXB (pertussis toxin B-oligomer)
  • uPA (urokinase plasminogen activator)

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Molecular Medicine

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