Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction

Luigi Emilio Pastormerlo, Chiara Mammini, Alberto Giannoni, Alessandro Valleggi, Concetta Prontera, Alessandra Gabutti, Roberta Poletti, Luigi Padeletti, Michele Emdin, Claudio Passino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims We aimed to evaluate the impact of glycometabolic imbalance as assessed by glycosylated haemoglobin [HbA(1c)] on neurohormonal activation and outcome in chronic heart failure (CHF). Methods and results Nine hundred and twenty CHF patients (65±12 years, left ventricular ejection fraction 33±10%, 29% diabetic patients) underwent a thorough humoral and clinical characterization, including HbA(1c), and were then followed up for the endpoint of cardiac death. In the whole population, diagnosis of diabetes resulted in no difference in neurohormonal or echocardiographic data, or in outcome. Conversely, the diabetic patients with HbA(1c) above 7% showed, in comparison to both diabetic patients with HbA(1c) below 7% and non-diabetic individuals, higher plasma renin activity (1.81, 0.48-5.68 vs. 1.23, 0.43-2.8 and 1.29, 0.44-5ng/ml/h, respectively; P

Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 6 2015

Fingerprint

Glycosylated Hemoglobin A
Left Ventricular Dysfunction
Heart Failure
Renin
Stroke Volume
Population

Keywords

  • diabetes
  • glycaemic control
  • heart failure
  • NT-pro-BNP
  • plasma renin activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction. / Pastormerlo, Luigi Emilio; Mammini, Chiara; Giannoni, Alberto; Valleggi, Alessandro; Prontera, Concetta; Gabutti, Alessandra; Poletti, Roberta; Padeletti, Luigi; Emdin, Michele; Passino, Claudio.

In: Journal of Cardiovascular Medicine, Vol. 16, No. 6, 06.06.2015, p. 423-430.

Research output: Contribution to journalArticle

Pastormerlo, LE, Mammini, C, Giannoni, A, Valleggi, A, Prontera, C, Gabutti, A, Poletti, R, Padeletti, L, Emdin, M & Passino, C 2015, 'Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction', Journal of Cardiovascular Medicine, vol. 16, no. 6, pp. 423-430. https://doi.org/10.2459/JCM.0000000000000159
Pastormerlo, Luigi Emilio ; Mammini, Chiara ; Giannoni, Alberto ; Valleggi, Alessandro ; Prontera, Concetta ; Gabutti, Alessandra ; Poletti, Roberta ; Padeletti, Luigi ; Emdin, Michele ; Passino, Claudio. / Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction. In: Journal of Cardiovascular Medicine. 2015 ; Vol. 16, No. 6. pp. 423-430.
@article{c58a6a9963d64060b47b4d3a1565641e,
title = "Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction",
abstract = "Aims We aimed to evaluate the impact of glycometabolic imbalance as assessed by glycosylated haemoglobin [HbA(1c)] on neurohormonal activation and outcome in chronic heart failure (CHF). Methods and results Nine hundred and twenty CHF patients (65±12 years, left ventricular ejection fraction 33±10{\%}, 29{\%} diabetic patients) underwent a thorough humoral and clinical characterization, including HbA(1c), and were then followed up for the endpoint of cardiac death. In the whole population, diagnosis of diabetes resulted in no difference in neurohormonal or echocardiographic data, or in outcome. Conversely, the diabetic patients with HbA(1c) above 7{\%} showed, in comparison to both diabetic patients with HbA(1c) below 7{\%} and non-diabetic individuals, higher plasma renin activity (1.81, 0.48-5.68 vs. 1.23, 0.43-2.8 and 1.29, 0.44-5ng/ml/h, respectively; P",
keywords = "diabetes, glycaemic control, heart failure, NT-pro-BNP, plasma renin activity",
author = "Pastormerlo, {Luigi Emilio} and Chiara Mammini and Alberto Giannoni and Alessandro Valleggi and Concetta Prontera and Alessandra Gabutti and Roberta Poletti and Luigi Padeletti and Michele Emdin and Claudio Passino",
year = "2015",
month = "6",
day = "6",
doi = "10.2459/JCM.0000000000000159",
language = "English",
volume = "16",
pages = "423--430",
journal = "Journal of Cardiovascular Medicine",
issn = "1558-2027",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction

AU - Pastormerlo, Luigi Emilio

AU - Mammini, Chiara

AU - Giannoni, Alberto

AU - Valleggi, Alessandro

AU - Prontera, Concetta

AU - Gabutti, Alessandra

AU - Poletti, Roberta

AU - Padeletti, Luigi

AU - Emdin, Michele

AU - Passino, Claudio

PY - 2015/6/6

Y1 - 2015/6/6

N2 - Aims We aimed to evaluate the impact of glycometabolic imbalance as assessed by glycosylated haemoglobin [HbA(1c)] on neurohormonal activation and outcome in chronic heart failure (CHF). Methods and results Nine hundred and twenty CHF patients (65±12 years, left ventricular ejection fraction 33±10%, 29% diabetic patients) underwent a thorough humoral and clinical characterization, including HbA(1c), and were then followed up for the endpoint of cardiac death. In the whole population, diagnosis of diabetes resulted in no difference in neurohormonal or echocardiographic data, or in outcome. Conversely, the diabetic patients with HbA(1c) above 7% showed, in comparison to both diabetic patients with HbA(1c) below 7% and non-diabetic individuals, higher plasma renin activity (1.81, 0.48-5.68 vs. 1.23, 0.43-2.8 and 1.29, 0.44-5ng/ml/h, respectively; P

AB - Aims We aimed to evaluate the impact of glycometabolic imbalance as assessed by glycosylated haemoglobin [HbA(1c)] on neurohormonal activation and outcome in chronic heart failure (CHF). Methods and results Nine hundred and twenty CHF patients (65±12 years, left ventricular ejection fraction 33±10%, 29% diabetic patients) underwent a thorough humoral and clinical characterization, including HbA(1c), and were then followed up for the endpoint of cardiac death. In the whole population, diagnosis of diabetes resulted in no difference in neurohormonal or echocardiographic data, or in outcome. Conversely, the diabetic patients with HbA(1c) above 7% showed, in comparison to both diabetic patients with HbA(1c) below 7% and non-diabetic individuals, higher plasma renin activity (1.81, 0.48-5.68 vs. 1.23, 0.43-2.8 and 1.29, 0.44-5ng/ml/h, respectively; P

KW - diabetes

KW - glycaemic control

KW - heart failure

KW - NT-pro-BNP

KW - plasma renin activity

UR - http://www.scopus.com/inward/record.url?scp=84929024070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929024070&partnerID=8YFLogxK

U2 - 10.2459/JCM.0000000000000159

DO - 10.2459/JCM.0000000000000159

M3 - Article

C2 - 25083720

AN - SCOPUS:84929024070

VL - 16

SP - 423

EP - 430

JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

IS - 6

ER -