Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction

Luigi Emilio Pastormerlo, Chiara Mammini, Alberto Giannoni, Alessandro Valleggi, Concetta Prontera, Alessandra Gabutti, Roberta Poletti, Luigi Padeletti, Michele Emdin, Claudio Passino

Research output: Contribution to journalArticle

Abstract

Aims We aimed to evaluate the impact of glycometabolic imbalance as assessed by glycosylated haemoglobin [HbA(1c)] on neurohormonal activation and outcome in chronic heart failure (CHF). Methods and results Nine hundred and twenty CHF patients (65±12 years, left ventricular ejection fraction 33±10%, 29% diabetic patients) underwent a thorough humoral and clinical characterization, including HbA(1c), and were then followed up for the endpoint of cardiac death. In the whole population, diagnosis of diabetes resulted in no difference in neurohormonal or echocardiographic data, or in outcome. Conversely, the diabetic patients with HbA(1c) above 7% showed, in comparison to both diabetic patients with HbA(1c) below 7% and non-diabetic individuals, higher plasma renin activity (1.81, 0.48-5.68 vs. 1.23, 0.43-2.8 and 1.29, 0.44-5ng/ml/h, respectively; P

Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 6 2015

Keywords

  • diabetes
  • glycaemic control
  • heart failure
  • NT-pro-BNP
  • plasma renin activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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    Pastormerlo, L. E., Mammini, C., Giannoni, A., Valleggi, A., Prontera, C., Gabutti, A., Poletti, R., Padeletti, L., Emdin, M., & Passino, C. (2015). Glycosylated haemoglobin is associated with neurohormonal activation and poor outcome in chronic heart failure patients with mild left ventricular systolic dysfunction. Journal of Cardiovascular Medicine, 16(6), 423-430. https://doi.org/10.2459/JCM.0000000000000159