Glycosylated proteins as an indicator of metabolic control in diabetes

evaluation by aminophenylboronic acid affinity chromatography.

A. Ceriello, P. dello Russo, F. Curcio, G. Paolisso, G. Illiano, S. Sgambato, D. Giugliano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glycosylated proteins, glycosylated albumin and HbA1 were studied in type I and type II diabetes. Glycosylated proteins were evaluated by a new method: aminophenylboronic acid affinity chromatography. A good correlation was found between total HbA1 and glycosylated proteins in both groups (r = 0.57, p less than 0.05; r = 0.67, p less than 0.01, respectively), but a positive correlation between stable HbA1 and glycosylated proteins was present only in maturity onset diabetics (r = 0.71, p less than 0.01). Glycosylated proteins correlated with glycosylated albumin only in type II diabetes (r = 0.67, p less than 0.01). We hypothesize that in maturity onset diabetes glycosylated proteins and HbA1 reflect a greater glycemic stability while in insulin-dependent diabetes the same proteins reflect a different periodic pattern of glycemic control. Moreover, our data suggest that aminophenylboronic acid affinity chromatography is a suitable tool for routine monitoring of metabolic control in maturity onset diabetes, while further investigations are needed to establish if this method is a useful index of altered glucose metabolism in type I diabetes.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalActa Diabetologica Latina
Volume21
Issue number1
Publication statusPublished - Jan 1984

Fingerprint

Affinity Chromatography
Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Proteins
Albumins
3-aminobenzeneboronic acid
Type 1 Diabetes Mellitus
Insulin
Glucose

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Glycosylated proteins as an indicator of metabolic control in diabetes : evaluation by aminophenylboronic acid affinity chromatography. / Ceriello, A.; dello Russo, P.; Curcio, F.; Paolisso, G.; Illiano, G.; Sgambato, S.; Giugliano, D.

In: Acta Diabetologica Latina, Vol. 21, No. 1, 01.1984, p. 49-54.

Research output: Contribution to journalArticle

Ceriello, A, dello Russo, P, Curcio, F, Paolisso, G, Illiano, G, Sgambato, S & Giugliano, D 1984, 'Glycosylated proteins as an indicator of metabolic control in diabetes: evaluation by aminophenylboronic acid affinity chromatography.', Acta Diabetologica Latina, vol. 21, no. 1, pp. 49-54.
Ceriello, A. ; dello Russo, P. ; Curcio, F. ; Paolisso, G. ; Illiano, G. ; Sgambato, S. ; Giugliano, D. / Glycosylated proteins as an indicator of metabolic control in diabetes : evaluation by aminophenylboronic acid affinity chromatography. In: Acta Diabetologica Latina. 1984 ; Vol. 21, No. 1. pp. 49-54.
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