Summary: Glycosylated hemoglobin and plasma proteins are the most important proteins in evaluating the glyco-metabolic balance of diabetic patients. They present different half-life which give them a different retrospectivity of the daily mean blood glucose. Besides the clinical use, the non enzymatic glycosilation has also a pathogenetic role in inducing the damage due to advanced glycosylation end products (AGEs) accumulation, leading to diabetic complications. An emerging role seems to have the glycosylated albumin determination. New and interesting methods are appearing. They seem to be more specific with respect to fructosamines and easy to perform in a routine laboratory. New approaches for personalized therapy in type 2 diabetes mellitus take into account these proteins, in particular HbA1c .
ASJC Scopus subject areas
- Biochemistry, medical
- Medical Laboratory Technology