Glycosylation pattern of platelet glycoprotein IIb and IIIa in type IIa hypercholesterolemia

Elisabetta Gianazza, Damiano Baldassarre, Silvia Michelagnoli, Paola Coari, Cesare R. Sirtori

Research output: Contribution to journalArticle

Abstract

The microheterogeneity and polymorphism of platelet membrane glycoproteins IIb and IIIa from hypercholesterolemic type IIA patients and from normolipidemic controls were compared by isoelectric focusing followed by immunological detection. Their size and the extent of glycosylation were investigated by polyacrylamide gel electrophoresis and carbohydrate affinity stain. No qualitative or quantitative differences could be detected, either within each test group or between the two groups. This finding rules out the hypothesis that altered molecular forms of the glycoproteins forming the fibrinogen receptor might be involved in the pathogenesis of platelet hyperaggregability in hypercholesterolemic patients.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalAtherosclerosis
Volume107
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Glycoprotein IIb.IIIa complex
  • Hypercholesterolemia
  • Microheterogeneity
  • Platelet membrane
  • Polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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