Abstract
The microheterogeneity and polymorphism of platelet membrane glycoproteins IIb and IIIa from hypercholesterolemic type IIA patients and from normolipidemic controls were compared by isoelectric focusing followed by immunological detection. Their size and the extent of glycosylation were investigated by polyacrylamide gel electrophoresis and carbohydrate affinity stain. No qualitative or quantitative differences could be detected, either within each test group or between the two groups. This finding rules out the hypothesis that altered molecular forms of the glycoproteins forming the fibrinogen receptor might be involved in the pathogenesis of platelet hyperaggregability in hypercholesterolemic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 221-227 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 107 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
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Keywords
- Glycoprotein IIb.IIIa complex
- Hypercholesterolemia
- Microheterogeneity
- Platelet membrane
- Polymorphism
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Glycosylation pattern of platelet glycoprotein IIb and IIIa in type IIa hypercholesterolemia. / Gianazza, Elisabetta; Baldassarre, Damiano; Michelagnoli, Silvia; Coari, Paola; Sirtori, Cesare R.
In: Atherosclerosis, Vol. 107, No. 2, 1994, p. 221-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glycosylation pattern of platelet glycoprotein IIb and IIIa in type IIa hypercholesterolemia
AU - Gianazza, Elisabetta
AU - Baldassarre, Damiano
AU - Michelagnoli, Silvia
AU - Coari, Paola
AU - Sirtori, Cesare R.
PY - 1994
Y1 - 1994
N2 - The microheterogeneity and polymorphism of platelet membrane glycoproteins IIb and IIIa from hypercholesterolemic type IIA patients and from normolipidemic controls were compared by isoelectric focusing followed by immunological detection. Their size and the extent of glycosylation were investigated by polyacrylamide gel electrophoresis and carbohydrate affinity stain. No qualitative or quantitative differences could be detected, either within each test group or between the two groups. This finding rules out the hypothesis that altered molecular forms of the glycoproteins forming the fibrinogen receptor might be involved in the pathogenesis of platelet hyperaggregability in hypercholesterolemic patients.
AB - The microheterogeneity and polymorphism of platelet membrane glycoproteins IIb and IIIa from hypercholesterolemic type IIA patients and from normolipidemic controls were compared by isoelectric focusing followed by immunological detection. Their size and the extent of glycosylation were investigated by polyacrylamide gel electrophoresis and carbohydrate affinity stain. No qualitative or quantitative differences could be detected, either within each test group or between the two groups. This finding rules out the hypothesis that altered molecular forms of the glycoproteins forming the fibrinogen receptor might be involved in the pathogenesis of platelet hyperaggregability in hypercholesterolemic patients.
KW - Glycoprotein IIb.IIIa complex
KW - Hypercholesterolemia
KW - Microheterogeneity
KW - Platelet membrane
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0028200832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028200832&partnerID=8YFLogxK
U2 - 10.1016/0021-9150(94)90023-X
DO - 10.1016/0021-9150(94)90023-X
M3 - Article
VL - 107
SP - 221
EP - 227
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -