GM1 ganglioside therapy in acute ischemic stroke

F. Angeleri, O. Scarpino, C. Martinazzo, A. Mauro, M. Magi, G. Pelliccioni, G. Rapex, Roberto Bruno

Research output: Contribution to journalArticlepeer-review


A double-blind, randomized, placebo-controlled clinical trial, involving two Italian centers, was carried out to evaluate the efficacy and safety of the mono-sialoganglioside GM1 in acute ischemic stroke. A total of 112 consecutive patients were recruited. The treatment (GM1 or placebo) was intravenously administered for 3 weeks and the follow-up lasted for 6 months. Semiquanti- tative clinical evaluations were performed on admission at the end of treat¬ment (day 21) and at the end of follow-up (day 180), by using the Frithz- Werner Scale for the neurological recovery and the Barthel Index for the activ¬ities of daily living. On day 21, the statistical analysis showed a significant neurological improvement (p <0.01) in the Frithz-Werner Scale in favor of the GM1 group. On day 180, the difference between the two groups was not significant for the Frithz-Werner Scale, while it reached significance for the activities of daily living (Barthel Index) in favor of the GM1 -treated group (p <0.05).

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalCerebrovascular Diseases
Issue number3
Publication statusPublished - 1992


  • Cerebral ischemia
  • Excitatory amino acids
  • GM1 ganglioside therapy
  • Monosialoganglioside

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology


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