GnRH agonists, synthetic analogs of GnRH, desensitize pituitary receptors for the native molecule, thus causing reversible hypogonatropic hypogonadism. Numerous clinical studies have suggested that these compounds are efficacious in the treatment of endomeytriosis, but it is not clear whether they are superior to the other drugs used in treatment of this disease. The frequency of recurrence of pain symptoms at the end of treatment is high and the data on recovery of fertility are conflicting. Long-term administration of GnRH agonists is a safe and well tolerated treatment but its role in the management of endometriosis is still not well defined.
|Number of pages||8|
|Journal||Acta Europaea Fertilitatis|
|Publication status||Published - 1988|
ASJC Scopus subject areas
- Obstetrics and Gynaecology