TY - JOUR
T1 - GnRH analogs for the treatment of symptomatic uterine leiomyomas
AU - Palomba, Stefano
AU - Falbo, Angela
AU - Russo, Tiziana
AU - Zullo, Fulvio
PY - 2005/4
Y1 - 2005/4
N2 - Uterine leiomyomas are the most frequent benign disease of the female reproductive tract. To date, the standard treatment of uterine leiomyomas is laparotomic/laparoscopic excision in women who want to preserve their fertility, whereas the use of a more extensive surgery, such as hysterectomy, is reserved for disseminated uterine leiomyomatosis, usually in the perimenopausal period. Given the pathogenesis of uterine leiomyomas, it is clear that future treatments for leiomyomas may be medical. At present the only clinically relevant medical treatment of uterine leiomyoma is GnRH agonist administration in depot formulations. In this review, the use of GnRH agonists, with or without "add-back therapy," and antagonists will be assessed.
AB - Uterine leiomyomas are the most frequent benign disease of the female reproductive tract. To date, the standard treatment of uterine leiomyomas is laparotomic/laparoscopic excision in women who want to preserve their fertility, whereas the use of a more extensive surgery, such as hysterectomy, is reserved for disseminated uterine leiomyomatosis, usually in the perimenopausal period. Given the pathogenesis of uterine leiomyomas, it is clear that future treatments for leiomyomas may be medical. At present the only clinically relevant medical treatment of uterine leiomyoma is GnRH agonist administration in depot formulations. In this review, the use of GnRH agonists, with or without "add-back therapy," and antagonists will be assessed.
KW - Add-back therapy
KW - GnRH agonist
KW - GnRH analog
KW - GnRH antagonist
KW - Uterine leiomyomas
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U2 - 10.1007/s10397-004-0078-0
DO - 10.1007/s10397-004-0078-0
M3 - Article
AN - SCOPUS:18744403979
VL - 2
SP - 7
EP - 13
JO - Gynecological Surgery
JF - Gynecological Surgery
SN - 1613-2076
IS - 1
ER -