GnRH receptors in human breast cancer and its contiguous not-involved breast tissue

Angelo Paradiso, A. Pezzetta, G. Cellamare, F. Schittulli, F. Marzullo, S. J. Reshkin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The present study was undertaken to evaluate the presence of GnRH receptors (GnRH-R) in breast cancer and not-involved breast tissue, and the relationships between GnRH-R and receptors for estrogen (ER) and progesterone (PgR) in the same tissues. Utilizing a tritiated natural GnRH in order to assay the native receptor binding we analyzed the level of binding sites for GnRH in membranes derived from 90 breast tumors and in 40 cases from neighboring, not-involved breast tissue. GnRH-R was found both in cancer and normal tissues. The prevalence for GnRH-R was higher in tumor than in not-tumor tissue (45% vs 39%, respectively), but the overall levels were not significantly different (15.9±24 fmol/mg protein vs 18.2±39 fmol/mg protein, respectively). The only statistically different content of GnRH-R we found concerned PgR negative vs PgR positive tumor tissues (mean content: 23 vs 11 fmol/mg protein, respectively in PgR- and PgR+ tumors, p=0.03 by t test); furthermore the proportion of GnRH-R positive cases in the tumor resulted significantly higher in premenopausal patients vs postmenopausal (56% vs 32%, by Chi square test, p

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalJournal of Endocrinological Investigation
Volume23
Issue number2
Publication statusPublished - 2000

Fingerprint

LHRH Receptors
Breast
Breast Neoplasms
Progesterone
Neoplasms
Gonadotropin-Releasing Hormone
Proteins
Progesterone Receptors
Chi-Square Distribution
Estrogen Receptors
Binding Sites
Membranes

Keywords

  • Breast cancer
  • GnRH receptor
  • Normal tissue
  • Steroid receptor

ASJC Scopus subject areas

  • Endocrinology

Cite this

Paradiso, A., Pezzetta, A., Cellamare, G., Schittulli, F., Marzullo, F., & Reshkin, S. J. (2000). GnRH receptors in human breast cancer and its contiguous not-involved breast tissue. Journal of Endocrinological Investigation, 23(2), 90-96.

GnRH receptors in human breast cancer and its contiguous not-involved breast tissue. / Paradiso, Angelo; Pezzetta, A.; Cellamare, G.; Schittulli, F.; Marzullo, F.; Reshkin, S. J.

In: Journal of Endocrinological Investigation, Vol. 23, No. 2, 2000, p. 90-96.

Research output: Contribution to journalArticle

Paradiso, A, Pezzetta, A, Cellamare, G, Schittulli, F, Marzullo, F & Reshkin, SJ 2000, 'GnRH receptors in human breast cancer and its contiguous not-involved breast tissue', Journal of Endocrinological Investigation, vol. 23, no. 2, pp. 90-96.
Paradiso, Angelo ; Pezzetta, A. ; Cellamare, G. ; Schittulli, F. ; Marzullo, F. ; Reshkin, S. J. / GnRH receptors in human breast cancer and its contiguous not-involved breast tissue. In: Journal of Endocrinological Investigation. 2000 ; Vol. 23, No. 2. pp. 90-96.
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