Gold branched nanoparticles for cellular treatments

Laura Sironi, Stefano Freddi, Michele Caccia, Paolo Pozzi, Leone Rossetti, Piersandro Pallavicini, Alice Donà, Elisa Cabrini, Maurizio Gualtieri, Ilaria Rivolta, Alice Panariti, Laura Dalfonso, Maddalena Collini, Giuseppe Chirico

Research output: Contribution to journalArticlepeer-review

Abstract

Under the action of near-infrared radiation, shape anisotropic gold nanoparticles emit two-photon luminescence and release heat. Accordingly, they have been proposed for imaging, photothermal therapies and thermo-controlled drug delivery. In all these applications particular care must be given to control the nanoparticle - cell interaction and the thermal efficiency of the nanoparticles, while minimizing their intrinsic cytotoxicity. We present here the characterization of the cell interaction of newly developed branched gold nanostars, obtained by laurylsulfobetaine-driven seed-growth synthesis. The study provides information on the size distribution, the shape anisotropy, the cellular uptake and cytotoxicity of the gold nanostars as well as their intracellular dynamic behavior by means of two-photon luminescence imaging, fluorescence correlation spectroscopy and particle tracking. The results show that the gold nanostars are internalized as well as the widely used gold nanorods and are less toxic under prolonged treatments. At the same time they display remarkable two-photon luminescence and large extinction under polarized light in the near-infrared region of the spectrum, 800-950 nm. Gold nanostars appear then a valuable alternative to other elongated or in-homogeneous nanoparticles for cell imaging.

Original languageEnglish
Pages (from-to)18407-18418
Number of pages12
JournalJournal of Physical Chemistry C
Volume116
Issue number34
DOIs
Publication statusPublished - Aug 30 2012

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Energy(all)

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