Gold nanoparticles and nanorods in nuclear medicine: A mini review

Daria Maccora, Valentina Dini, Chiara Battocchio, Ilaria Fratoddi, Antonella Cartoni, Dante Rotili, Massimo Castagnola, Riccardo Faccini, Isabella Bruno, Teresa Scotognella, Alessandro Giordano, Iole Venditti

Research output: Contribution to journalReview article

Abstract

In the last decade, many innovative nanodrugs have been developed, as well as many nanoradiocompounds that show amazing features in nuclear imaging and/or radiometabolic therapy. Their potential uses offer a wide range of possibilities. It can be possible to develop nondimensional systems of existing radiopharmaceuticals or build engineered systems that combine a nanoparticle with the radiopharmaceutical, a tracer, and a target molecule, and still develop selective nanodetection systems. This review focuses on recent advances regarding the use of gold nanoparticles and nanorods in nuclear medicine. The up-to-date advancements will be shown concerning preparations with special attention on the dimensions and functionalizations that are most used to attain an enhanced performance of gold engineered nanomaterials. Many ideas are offered regarding recent in vitro and in vivo studies. Finally, the recent clinical trials and applications are discussed.

Original languageEnglish
Article number3232
JournalApplied Sciences (Switzerland)
Volume9
Issue number16
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Drug delivery
  • Gold nanoparticles
  • Gold nanorods
  • Nanomedicine
  • Nanoradiocompounds
  • Nuclear medicine
  • Radiopharmaceuticals
  • Theragnostic

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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  • Cite this

    Maccora, D., Dini, V., Battocchio, C., Fratoddi, I., Cartoni, A., Rotili, D., Castagnola, M., Faccini, R., Bruno, I., Scotognella, T., Giordano, A., & Venditti, I. (2019). Gold nanoparticles and nanorods in nuclear medicine: A mini review. Applied Sciences (Switzerland), 9(16), [3232]. https://doi.org/10.3390/app9163232