TY - JOUR
T1 - GOLPH3 and oncogenesis
T2 - What is the molecular link?
AU - Rizzo, Riccardo
AU - Parashuraman, Seetharaman
AU - D'Angelo, Giovanni
AU - Luini, Alberto
PY - 2016/5/16
Y1 - 2016/5/16
N2 - The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN). It regulates several cellular functions like Golgi vesicular trafficking, Golgi glycosylation and mitochondrial cardiolipin production. Recently, GOLPH3 was discovered to be part of the DNA damage response signalling pathway, with a role in cell survival following DNA damage. In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.
AB - The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN). It regulates several cellular functions like Golgi vesicular trafficking, Golgi glycosylation and mitochondrial cardiolipin production. Recently, GOLPH3 was discovered to be part of the DNA damage response signalling pathway, with a role in cell survival following DNA damage. In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.
KW - Cancer
KW - Glycosylation
KW - Golgi
KW - GOLPH3
KW - Membrane trafficking
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U2 - 10.1016/j.tice.2016.06.008
DO - 10.1016/j.tice.2016.06.008
M3 - Article
AN - SCOPUS:85004130223
JO - Tissue and Cell
JF - Tissue and Cell
SN - 0040-8166
ER -