GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo; Seetharaman Parashuraman; Giovanni D'Angelo; Alberto Luini

doi:10.1016/j.tice.2016.06.008

GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo, Seetharaman Parashuraman, Giovanni D'Angelo, Alberto Luini

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN). It regulates several cellular functions like Golgi vesicular trafficking, Golgi glycosylation and mitochondrial cardiolipin production. Recently, GOLPH3 was discovered to be part of the DNA damage response signalling pathway, with a role in cell survival following DNA damage. In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.

Original language	English
Journal	Tissue and Cell
DOIs	https://doi.org/10.1016/j.tice.2016.06.008
Publication status	Accepted/In press - May 16 2016

Keywords

Cancer
Glycosylation
Golgi
GOLPH3
Membrane trafficking

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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title = "GOLPH3 and oncogenesis: What is the molecular link?",

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AU - Luini, Alberto

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