Gonadal damage in Hodgkin's disease from cancer chemotherapeutic regimens

G. Bonadonna, A. Santoro, S. Viviani

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The paper re-emphasizes that intesive prolonged anticancer chemotherapy containing alkylating agents or procarbazine or both produces a high-incidence of gonadal failure, particularly in males. This evidence has been documented mostly in patients with Hodgkin's disease. On the contrary, effective combination regimens, such as ABVD, not including the above mentioned drugs induce a comparatively less and transient germ cell toxicity. In devising chemotherapy for potentially curable neoplastic diseases in young patients efforts should be made to avoid or minimize the potential risk of drug-induced gonadal failure.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalArchives of Toxicology
Volume55
Issue numberSUPPL. 7
DOIs
Publication statusPublished - 1984

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Chemotherapy
Hodgkin Disease
Procarbazine
Drug Therapy
Alkylating Agents
Germ Cells
Pharmaceutical Preparations
Toxicity
Neoplasms
Cells
Incidence

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Gonadal damage in Hodgkin's disease from cancer chemotherapeutic regimens. / Bonadonna, G.; Santoro, A.; Viviani, S.

In: Archives of Toxicology, Vol. 55, No. SUPPL. 7, 1984, p. 140-145.

Research output: Contribution to journalArticle

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