Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT

Maura Faraci, Tamara Diesch, Myriam Labopin, Arnaud Dalissier, Arian Lankester, Andrew Gennery, Mikael Sundin, Duygu Uckan-Cetinkaya, Marc Bierings, Anke M J Peters, Martina Garwer, Ansgar Schulz, Gerard Michel, Giovanna Giorgiani, Bernd Gruhn, Franco Locatelli, Stefano Giardino, Anne Uyttebroeck, Fanny Rialland, Maija Itäla-RemesPeter Dreger, Peter J Shaw, Victoria Bordon, Paul G Schlegel, Karin Mellgren, Jose M Moraleda, Katharine Patrick, Pascale Schneider, Charlotte Jubert, Anita Lawitschka, Nina Salooja, Grzegorz W Basak, Selim Corbaciuoglu, Rafael Duarte, Peter Bader

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Gonadal impairment is an important late effect having a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after Busulfan (Bu) or Treosulfan (Treo) conditioning regimens in pre and post-pubertal children.

MATERIAL AND METHODS: This is a retrospective, multicenter study including children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemo-radiotherapy before the transplant.

RESULTS: We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range 5-18); 89 patients were males and 48 were females. Eighty-nine patients were pre-pubertal at transplant, while 48 were post-pubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of females treated with Treo in pre-pubertal stage reached spontaneous puberty compared to those treated with Bu (p=0.02). Spontaneous menarche was more frequent after Treo than after Bu (p< 0.001). Post-pubertal males and females treated with Treo had significantly lower luteinizing hormone (LH) levels (p=0.03 and p=0.04, respectively) compared to the Bu group.

CONCLUSIONS: Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

Original languageEnglish
JournalBiology of Blood and Marrow Transplantation
DOIs
Publication statusE-pub ahead of print - May 10 2019

Fingerprint

treosulfan
Busulfan
Hematopoietic Stem Cell Transplantation
Transplantation
Bone Marrow
Pediatrics
Transplants
Menarche
Puberty
Luteinizing Hormone
Multicenter Studies
Radiotherapy
Retrospective Studies
Quality of Life

Cite this

Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT. / Faraci, Maura; Diesch, Tamara; Labopin, Myriam; Dalissier, Arnaud; Lankester, Arian; Gennery, Andrew; Sundin, Mikael; Uckan-Cetinkaya, Duygu; Bierings, Marc; Peters, Anke M J; Garwer, Martina; Schulz, Ansgar; Michel, Gerard; Giorgiani, Giovanna; Gruhn, Bernd; Locatelli, Franco; Giardino, Stefano; Uyttebroeck, Anne; Rialland, Fanny; Itäla-Remes, Maija; Dreger, Peter; Shaw, Peter J; Bordon, Victoria; Schlegel, Paul G; Mellgren, Karin; Moraleda, Jose M; Patrick, Katharine; Schneider, Pascale; Jubert, Charlotte; Lawitschka, Anita; Salooja, Nina; Basak, Grzegorz W; Corbaciuoglu, Selim; Duarte, Rafael; Bader, Peter.

In: Biology of Blood and Marrow Transplantation, 10.05.2019.

Research output: Contribution to journalArticle

Faraci, M, Diesch, T, Labopin, M, Dalissier, A, Lankester, A, Gennery, A, Sundin, M, Uckan-Cetinkaya, D, Bierings, M, Peters, AMJ, Garwer, M, Schulz, A, Michel, G, Giorgiani, G, Gruhn, B, Locatelli, F, Giardino, S, Uyttebroeck, A, Rialland, F, Itäla-Remes, M, Dreger, P, Shaw, PJ, Bordon, V, Schlegel, PG, Mellgren, K, Moraleda, JM, Patrick, K, Schneider, P, Jubert, C, Lawitschka, A, Salooja, N, Basak, GW, Corbaciuoglu, S, Duarte, R & Bader, P 2019, 'Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT', Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2019.05.005
Faraci, Maura ; Diesch, Tamara ; Labopin, Myriam ; Dalissier, Arnaud ; Lankester, Arian ; Gennery, Andrew ; Sundin, Mikael ; Uckan-Cetinkaya, Duygu ; Bierings, Marc ; Peters, Anke M J ; Garwer, Martina ; Schulz, Ansgar ; Michel, Gerard ; Giorgiani, Giovanna ; Gruhn, Bernd ; Locatelli, Franco ; Giardino, Stefano ; Uyttebroeck, Anne ; Rialland, Fanny ; Itäla-Remes, Maija ; Dreger, Peter ; Shaw, Peter J ; Bordon, Victoria ; Schlegel, Paul G ; Mellgren, Karin ; Moraleda, Jose M ; Patrick, Katharine ; Schneider, Pascale ; Jubert, Charlotte ; Lawitschka, Anita ; Salooja, Nina ; Basak, Grzegorz W ; Corbaciuoglu, Selim ; Duarte, Rafael ; Bader, Peter. / Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT. In: Biology of Blood and Marrow Transplantation. 2019.
@article{ad0cafc3c0454228938b6deb3e777b7d,
title = "Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT",
abstract = "INTRODUCTION: Gonadal impairment is an important late effect having a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after Busulfan (Bu) or Treosulfan (Treo) conditioning regimens in pre and post-pubertal children.MATERIAL AND METHODS: This is a retrospective, multicenter study including children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemo-radiotherapy before the transplant.RESULTS: We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range 5-18); 89 patients were males and 48 were females. Eighty-nine patients were pre-pubertal at transplant, while 48 were post-pubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of females treated with Treo in pre-pubertal stage reached spontaneous puberty compared to those treated with Bu (p=0.02). Spontaneous menarche was more frequent after Treo than after Bu (p< 0.001). Post-pubertal males and females treated with Treo had significantly lower luteinizing hormone (LH) levels (p=0.03 and p=0.04, respectively) compared to the Bu group.CONCLUSIONS: Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.",
author = "Maura Faraci and Tamara Diesch and Myriam Labopin and Arnaud Dalissier and Arian Lankester and Andrew Gennery and Mikael Sundin and Duygu Uckan-Cetinkaya and Marc Bierings and Peters, {Anke M J} and Martina Garwer and Ansgar Schulz and Gerard Michel and Giovanna Giorgiani and Bernd Gruhn and Franco Locatelli and Stefano Giardino and Anne Uyttebroeck and Fanny Rialland and Maija It{\"a}la-Remes and Peter Dreger and Shaw, {Peter J} and Victoria Bordon and Schlegel, {Paul G} and Karin Mellgren and Moraleda, {Jose M} and Katharine Patrick and Pascale Schneider and Charlotte Jubert and Anita Lawitschka and Nina Salooja and Basak, {Grzegorz W} and Selim Corbaciuoglu and Rafael Duarte and Peter Bader",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "5",
day = "10",
doi = "10.1016/j.bbmt.2019.05.005",
language = "English",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Gonadal function after Busulfan compared to Treosulfan in children and adolescents undergoing allogeneic hematopoietic stem cell transplantation. On Behalf of the Pediatric and Transplant Complications Working Parties of EBMT

AU - Faraci, Maura

AU - Diesch, Tamara

AU - Labopin, Myriam

AU - Dalissier, Arnaud

AU - Lankester, Arian

AU - Gennery, Andrew

AU - Sundin, Mikael

AU - Uckan-Cetinkaya, Duygu

AU - Bierings, Marc

AU - Peters, Anke M J

AU - Garwer, Martina

AU - Schulz, Ansgar

AU - Michel, Gerard

AU - Giorgiani, Giovanna

AU - Gruhn, Bernd

AU - Locatelli, Franco

AU - Giardino, Stefano

AU - Uyttebroeck, Anne

AU - Rialland, Fanny

AU - Itäla-Remes, Maija

AU - Dreger, Peter

AU - Shaw, Peter J

AU - Bordon, Victoria

AU - Schlegel, Paul G

AU - Mellgren, Karin

AU - Moraleda, Jose M

AU - Patrick, Katharine

AU - Schneider, Pascale

AU - Jubert, Charlotte

AU - Lawitschka, Anita

AU - Salooja, Nina

AU - Basak, Grzegorz W

AU - Corbaciuoglu, Selim

AU - Duarte, Rafael

AU - Bader, Peter

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/5/10

Y1 - 2019/5/10

N2 - INTRODUCTION: Gonadal impairment is an important late effect having a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after Busulfan (Bu) or Treosulfan (Treo) conditioning regimens in pre and post-pubertal children.MATERIAL AND METHODS: This is a retrospective, multicenter study including children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemo-radiotherapy before the transplant.RESULTS: We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range 5-18); 89 patients were males and 48 were females. Eighty-nine patients were pre-pubertal at transplant, while 48 were post-pubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of females treated with Treo in pre-pubertal stage reached spontaneous puberty compared to those treated with Bu (p=0.02). Spontaneous menarche was more frequent after Treo than after Bu (p< 0.001). Post-pubertal males and females treated with Treo had significantly lower luteinizing hormone (LH) levels (p=0.03 and p=0.04, respectively) compared to the Bu group.CONCLUSIONS: Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

AB - INTRODUCTION: Gonadal impairment is an important late effect having a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after Busulfan (Bu) or Treosulfan (Treo) conditioning regimens in pre and post-pubertal children.MATERIAL AND METHODS: This is a retrospective, multicenter study including children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemo-radiotherapy before the transplant.RESULTS: We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range 5-18); 89 patients were males and 48 were females. Eighty-nine patients were pre-pubertal at transplant, while 48 were post-pubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of females treated with Treo in pre-pubertal stage reached spontaneous puberty compared to those treated with Bu (p=0.02). Spontaneous menarche was more frequent after Treo than after Bu (p< 0.001). Post-pubertal males and females treated with Treo had significantly lower luteinizing hormone (LH) levels (p=0.03 and p=0.04, respectively) compared to the Bu group.CONCLUSIONS: Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

U2 - 10.1016/j.bbmt.2019.05.005

DO - 10.1016/j.bbmt.2019.05.005

M3 - Article

C2 - 31082473

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

ER -