STUDIO DELLA FUNZIONALITA GONADICA IN ADOLESCENTI SOTTOPOSTI AD IRRADIAZIONE TOTALE CORPOREA (TBI) PER TRAPIANTO DI MIDOLLO OSSEO (TMO)

Translated title of the contribution: Gonadal function in young patients subjected to total body irradiation

D. Gambarana, P. Tonani, M. Bongiorno, C. Focardi, I. Biscaldi, R. M. Cerbo

Research output: Contribution to journalArticle

Abstract

Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.

Translated title of the contributionGonadal function in young patients subjected to total body irradiation
Original languageItalian
Pages (from-to)152-154
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine(all)

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