STUDIO DELLA FUNZIONALITA GONADICA IN ADOLESCENTI SOTTOPOSTI AD IRRADIAZIONE TOTALE CORPOREA (TBI) PER TRAPIANTO DI MIDOLLO OSSEO (TMO)

Translated title of the contribution: Gonadal function in young patients subjected to total body irradiation

D. Gambarana, P. Tonani, M. Bongiorno, C. Focardi, I. Biscaldi, R. M. Cerbo

Research output: Contribution to journalArticle

Abstract

Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.

Original languageItalian
Pages (from-to)152-154
Number of pages3
JournalMedicina - Rivista della Enciclopedia Medica Italiana
Volume10
Issue number2
Publication statusPublished - 1990

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Whole-Body Irradiation
Gonadotropins
Gonadal Hormones
Radiation Injuries
Sexual Development
Pituitary Hormones
Radiation Effects
Bone Marrow Transplantation
Testosterone
Testis
Ovary
Estradiol
Transplantation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

STUDIO DELLA FUNZIONALITA GONADICA IN ADOLESCENTI SOTTOPOSTI AD IRRADIAZIONE TOTALE CORPOREA (TBI) PER TRAPIANTO DI MIDOLLO OSSEO (TMO). / Gambarana, D.; Tonani, P.; Bongiorno, M.; Focardi, C.; Biscaldi, I.; Cerbo, R. M.

In: Medicina - Rivista della Enciclopedia Medica Italiana, Vol. 10, No. 2, 1990, p. 152-154.

Research output: Contribution to journalArticle

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abstract = "Gonadal impairment has been observed in patients who underwent bone marrow transplantation with TBI-containing cytoreductive regimen. In order to study the effects of radiations on the pituitary and gonadal hormones 12-18 months after transplantation sexual development and plasma levels of gonadotropins, estradiol, and testosterone were evaluated in 9 patients (4 boys and 5 girls, age range 11-20 years). The preliminary results of this study show that TBI produces in both sexes a gonadal impairment, as shown by the high plasma levels of gonadotropins. Nevertheless, the gonadal damage seems to be more important in girls and we suppose a greater sensitivity to radiation injury of the ovary than of the testis.",
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AU - Biscaldi, I.

AU - Cerbo, R. M.

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