Gonadal toxicity after combination chemotherapy for Hodgkin's disease. Comparative results of MOPP vs ABVD

S. Viviani, A. Santoro, G. Ragni, V. Bonfante, O. Bestetti, G. Bonadonna

Research output: Contribution to journalArticlepeer-review

Abstract

The comparative gonadal toxicity following two equally effective and non-cross-resistant regimens (MOPP and ABVD) was prospectively evaluated in 53 males with Hodgkin's disease. The median age was 29 yr (range 16-15). MOPP produced azoospermia in 28/29 patients (97%) while ABVD induced oligoazoospermia in 13/24 patients (54%). Follicle-stimulating hormone levels were consistently and significantly increased after MOPP while their median value remained within normal range after ABVD. Sperm count was repeated in 34 patients. Recovery of spermatogenesis occurred in 3/21 cases treated with MOPP and in all 13 cases given ABVD. Present findings confirm that the two alkylating agents, mechlorethamine and procarbazine, included in the MOPP regimen cause sterility in most patients while the drugs included in ABVD are not associated with permanent gonadal dysfunction.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume21
Issue number5
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Oncology

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