Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium

Stephan J. Reshkin, Valentina Albarani, Antonia Pezzetta, Marco Marinaccio, Angelo Paradiso

Research output: Contribution to journalArticle

Abstract

The present study evaluated the presence of GnRH-R in leiomyomas, in associated, non-involved uterine tissues (myometrium and endometrium) and the possible relationships between GnRH-R and the receptors for estrogen and progesterone in the same tissues. GnRH-R was found in all uterine tissues and both GnRH and the GnRH analog, goserelin, displaced its binding consistent with a single type of high affinity receptor (Kd≃10-8 M). GnRH-R were found more frequently in myometrium (81% of samples) than in endometrium (58%) or leiomyoma (42%). However, the mean receptor content was lowest in myometrium (139±19 fmol/mg protein) with both leiomyomas (288±77 fmol/mg protein) and endometrium (372±96 fmol/mg protein) having significantly higher values. Endometrial GnRH binding varied from 596±42 in uteri that were GnRH-R positive in the endothelium alone to 231±49 when GnRH-R was present also in the other tissues. Endometrium negative for the GnRH-R had significantly higher levels of estrogen receptor than all the other uterine samples (266±25 vs 614±7.5 fmol/mg protein, respectively). Endometrial GnRH-R seem to be dependent on its presence and/or level in other uterine tissues. Further, when GnRH-R is absent in the endometrium this tissue expresses greatly increased levels of steroid receptors.

Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalInternational Journal of Oncology
Volume11
Issue number3
Publication statusPublished - 1997

Keywords

  • GnRH
  • Leiomyoma
  • Steroid receptors
  • Uterus

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium'. Together they form a unique fingerprint.

  • Cite this