Gonadotropin releasing hormone agonist for chronic anovulatory uterine bleeding and severe anemia

P. Vercellini, L. Fedele, R. Maggi, N. Vendola, L. Bocciolone, A. Colombo

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Twenty-three women with chronic heavy anovulatory uterine bleeding and severe iron-deficiency anemia received six months' treatment with goserelin, a gonadotropin releasing hormone agonist, administered as a monthly subcutaneous depot. After two months of treatment, all patients were amenorrheic and subsequent spotting was reported on only nine occasions. Laboratory results showed the following values: mean hemoglobin before treatment, 7.9 g/dL-13.8 g/dL at six months (+75%); mean hematocrit, 26.3%- 41.6% (+58); mean serum iron, 19.8 μg/dL-63.3 μg/dL (+134%) and mean serum ferritin, 6.2 ng/mL-35.3 ng/mL (+469%). The endometrial hyperplasia observed in 11 subjects showed regression at follow-up suction biopsy. Gonadotropin releasing hormone agonists administered in a depot formulation for a few months in highly selected patients with severe anemia associated with heavy anovulatory uterine bleeding are practical, safe and effective, may avoid blood transfusions and could be used as a first line of treatment.

Original languageEnglish
Pages (from-to)127-129
Number of pages3
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number2
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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