Gonadotropin releasing hormone elicits abnormal hormone responses in schizophrenia

L. Cantalamessa, A. Catania, A. Silva, A. Orsatti, P. Motta, C. L. Cazzullo

Research output: Contribution to journalArticlepeer-review


We studied the non-specific responses of GH and PRL to gonadotropin releasing hormone (GnRH) in eleven male patients aged 18-30 in whom a diagnosis of acute schizophrenia was made according to Crow's criteria. GnRH administration was followed by a significant increase in plasma GH in five patients; plasma PRL increased in two patients. The two prolactin responders were also GH responders. Non-specific GH response was confirmed on repeated testing in two patients in whom GnRH stimulation was performed twice. During saline control, non-specific hormone responses were not observed. The abnormal hormone responses observed in acute schizophrenia are probably due to the disordered monoamine regulation characteristic of this condition.

Original languageEnglish
Pages (from-to)481-484
Number of pages4
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)


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