Gonadotropin releasing hormone elicits abnormal hormone responses in schizophrenia

L. Cantalamessa; A. Catania; A. Silva; A. Orsatti; P. Motta; C. L. Cazzullo

doi:10.1016/0306-4530(85)90088-5

Gonadotropin releasing hormone elicits abnormal hormone responses in schizophrenia

L. Cantalamessa, A. Catania, A. Silva, A. Orsatti, P. Motta, C. L. Cazzullo

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the non-specific responses of GH and PRL to gonadotropin releasing hormone (GnRH) in eleven male patients aged 18-30 in whom a diagnosis of acute schizophrenia was made according to Crow's criteria. GnRH administration was followed by a significant increase in plasma GH in five patients; plasma PRL increased in two patients. The two prolactin responders were also GH responders. Non-specific GH response was confirmed on repeated testing in two patients in whom GnRH stimulation was performed twice. During saline control, non-specific hormone responses were not observed. The abnormal hormone responses observed in acute schizophrenia are probably due to the disordered monoamine regulation characteristic of this condition.

Original language	English
Pages (from-to)	481-484
Number of pages	4
Journal	Psychoneuroendocrinology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0306-4530(85)90088-5
Publication status	Published - 1985

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Psychiatry and Mental health
Biological Psychiatry
Endocrine and Autonomic Systems
Psychology(all)

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abstract = "We studied the non-specific responses of GH and PRL to gonadotropin releasing hormone (GnRH) in eleven male patients aged 18-30 in whom a diagnosis of acute schizophrenia was made according to Crow's criteria. GnRH administration was followed by a significant increase in plasma GH in five patients; plasma PRL increased in two patients. The two prolactin responders were also GH responders. Non-specific GH response was confirmed on repeated testing in two patients in whom GnRH stimulation was performed twice. During saline control, non-specific hormone responses were not observed. The abnormal hormone responses observed in acute schizophrenia are probably due to the disordered monoamine regulation characteristic of this condition.",

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AU - Cantalamessa, L.

AU - Catania, A.

AU - Silva, A.

AU - Orsatti, A.

AU - Motta, P.

AU - Cazzullo, C. L.

PY - 1985

Y1 - 1985

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AB - We studied the non-specific responses of GH and PRL to gonadotropin releasing hormone (GnRH) in eleven male patients aged 18-30 in whom a diagnosis of acute schizophrenia was made according to Crow's criteria. GnRH administration was followed by a significant increase in plasma GH in five patients; plasma PRL increased in two patients. The two prolactin responders were also GH responders. Non-specific GH response was confirmed on repeated testing in two patients in whom GnRH stimulation was performed twice. During saline control, non-specific hormone responses were not observed. The abnormal hormone responses observed in acute schizophrenia are probably due to the disordered monoamine regulation characteristic of this condition.

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Gonadotropin releasing hormone elicits abnormal hormone responses in schizophrenia

Abstract

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