Good practice in the management of amyotrophic lateral sclerosis: Clinical guidelines. An evidence-based review with good practice points. EALSC Working Group

Peter Munch Andersen, Gian Domenico Borasio, Reinhard Dengler, Orla Hardiman, Katja Kollewe, Peter Nigel Leigh, Pierre Francois Pradat, Vincenzo Silani, Barbara Tomik

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The evidence base for diagnosis and management of ALS is still weak, and curative therapy is lacking. Nonetheless, early diagnosis and symptomatic therapy can profoundly influence care and quality of life of the patient and relatives, and may increase survival time. This review addresses the current optimal clinical approach to ALS. The literature search is complete to December 2006. Where there was lack of evidence but consensus was clear we have stated our opinion as good practice points. We conclude that a diagnosis of ALS can be achieved by early examination by an experienced neurologist. The patient should be informed of the diagnosis by the consultant. Following diagnosis, a multi-diciplinary care team should support the patient and relatives. Medication with riluzole should be initiated as early as possible. PEG is associated with improved nutrition and should be inserted early. The operation is hazardous in patients with VC

Original languageEnglish
Pages (from-to)195-213
Number of pages19
JournalAmyotrophic Lateral Sclerosis
Volume8
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Practice Management
Amyotrophic Lateral Sclerosis
Guidelines
Riluzole
Consultants
Early Diagnosis
Consensus
Quality of Life
Survival
Therapeutics

Keywords

  • ALS/SLA/MND
  • Breaking the diagnosis
  • Bronchial secretions
  • Diagnosis
  • DNA-testing
  • Drooling
  • EALSC
  • Nutrition
  • Palliative care
  • Symptomatic treatment
  • Terminal care
  • Ventilation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Good practice in the management of amyotrophic lateral sclerosis : Clinical guidelines. An evidence-based review with good practice points. EALSC Working Group. / Andersen, Peter Munch; Borasio, Gian Domenico; Dengler, Reinhard; Hardiman, Orla; Kollewe, Katja; Leigh, Peter Nigel; Pradat, Pierre Francois; Silani, Vincenzo; Tomik, Barbara.

In: Amyotrophic Lateral Sclerosis, Vol. 8, No. 4, 2007, p. 195-213.

Research output: Contribution to journalArticle

Andersen, Peter Munch ; Borasio, Gian Domenico ; Dengler, Reinhard ; Hardiman, Orla ; Kollewe, Katja ; Leigh, Peter Nigel ; Pradat, Pierre Francois ; Silani, Vincenzo ; Tomik, Barbara. / Good practice in the management of amyotrophic lateral sclerosis : Clinical guidelines. An evidence-based review with good practice points. EALSC Working Group. In: Amyotrophic Lateral Sclerosis. 2007 ; Vol. 8, No. 4. pp. 195-213.
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