TY - JOUR
T1 - Good practice in the management of amyotrophic lateral sclerosis
T2 - Clinical guidelines. An evidence-based review with good practice points. EALSC Working Group
AU - Andersen, Peter Munch
AU - Borasio, Gian Domenico
AU - Dengler, Reinhard
AU - Hardiman, Orla
AU - Kollewe, Katja
AU - Leigh, Peter Nigel
AU - Pradat, Pierre Francois
AU - Silani, Vincenzo
AU - Tomik, Barbara
PY - 2007
Y1 - 2007
N2 - The evidence base for diagnosis and management of ALS is still weak, and curative therapy is lacking. Nonetheless, early diagnosis and symptomatic therapy can profoundly influence care and quality of life of the patient and relatives, and may increase survival time. This review addresses the current optimal clinical approach to ALS. The literature search is complete to December 2006. Where there was lack of evidence but consensus was clear we have stated our opinion as good practice points. We conclude that a diagnosis of ALS can be achieved by early examination by an experienced neurologist. The patient should be informed of the diagnosis by the consultant. Following diagnosis, a multi-diciplinary care team should support the patient and relatives. Medication with riluzole should be initiated as early as possible. PEG is associated with improved nutrition and should be inserted early. The operation is hazardous in patients with VC
AB - The evidence base for diagnosis and management of ALS is still weak, and curative therapy is lacking. Nonetheless, early diagnosis and symptomatic therapy can profoundly influence care and quality of life of the patient and relatives, and may increase survival time. This review addresses the current optimal clinical approach to ALS. The literature search is complete to December 2006. Where there was lack of evidence but consensus was clear we have stated our opinion as good practice points. We conclude that a diagnosis of ALS can be achieved by early examination by an experienced neurologist. The patient should be informed of the diagnosis by the consultant. Following diagnosis, a multi-diciplinary care team should support the patient and relatives. Medication with riluzole should be initiated as early as possible. PEG is associated with improved nutrition and should be inserted early. The operation is hazardous in patients with VC
KW - ALS/SLA/MND
KW - Breaking the diagnosis
KW - Bronchial secretions
KW - Diagnosis
KW - DNA-testing
KW - Drooling
KW - EALSC
KW - Nutrition
KW - Palliative care
KW - Symptomatic treatment
KW - Terminal care
KW - Ventilation
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U2 - 10.1080/17482960701262376
DO - 10.1080/17482960701262376
M3 - Article
C2 - 17653917
AN - SCOPUS:34547562663
VL - 8
SP - 195
EP - 213
JO - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
JF - Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
SN - 1466-0822
IS - 4
ER -