GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery: early analysis on 977 patients

The SIOG surgical task force/ESSO GOSAFE study group, Davide Pertile, Andrea Massobrio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Older patients with cancer value functional outcomes as much as survival, but surgical studies lack functional recovery (FR) data. The value of a standardized frailty assessment has been confirmed, yet it's infrequently utilized due to time restrictions into everyday practice. The multicenter GOSAFE study was designed to (1) evaluate the trajectory of patients' quality of life (QoL) after cancer surgery (2) assess baseline frailty indicators in unselected patients (3) clarify the most relevant tools in predicting FR and clinical outcomes. This is a report of the study design and baseline patient evaluations. Materials & Methods: GOSAFE prospectively collected a baseline multidimensional evaluation before major elective surgery in patients (≥70 years) from 26 international units. Short−/mid−/long-term surgical outcomes were recorded with QoL and FR data. Results: 1003 patients were enrolled in a 26-month span. Complete baseline data were available for 977(97.4%). Median age was 78 years (range 70–94); 52.8% males. 968(99%) lived at home, 51.6% without caregiver. 54.4% had ≥ 3 medications, 5.9% none. Patients were dependent (ADL < 5) in 7.9% of the cases. Frailty was either detected by G8 ≤ 14(68.4%), fTRST ≥ 2(37.4%), TUG > 20 s (5.2%) or ASAIII-IV (48.8%). Major comorbidities (CACI > 6) were detected in 36%; 20.9% of patients had cognitive impairment according to Mini-Cog. Conclusion: The GOSAFE showed that frailty is frequent in older patients undergoing cancer surgery. QoL and FR, for the first time, are going to be primary outcomes of a real-life observational study. The crucial role of frailty assessment is going to be addressed in the ability to predict postoperative outcomes and to correlate with QoL and FR.

Original languageEnglish
JournalJournal of Geriatric Oncology
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Geriatrics
Quality of Life
Surgical Oncology
Neoplasms
Aptitude
Activities of Daily Living
Caregivers
Multicenter Studies
Observational Studies
Comorbidity
Survival

ASJC Scopus subject areas

  • Oncology
  • Geriatrics and Gerontology

Cite this

GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery : early analysis on 977 patients. / The SIOG surgical task force/ESSO GOSAFE study group; Pertile, Davide; Massobrio, Andrea.

In: Journal of Geriatric Oncology, 01.01.2019.

Research output: Contribution to journalArticle

The SIOG surgical task force/ESSO GOSAFE study group ; Pertile, Davide ; Massobrio, Andrea. / GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery : early analysis on 977 patients. In: Journal of Geriatric Oncology. 2019.
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title = "GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery: early analysis on 977 patients",
abstract = "Objective: Older patients with cancer value functional outcomes as much as survival, but surgical studies lack functional recovery (FR) data. The value of a standardized frailty assessment has been confirmed, yet it's infrequently utilized due to time restrictions into everyday practice. The multicenter GOSAFE study was designed to (1) evaluate the trajectory of patients' quality of life (QoL) after cancer surgery (2) assess baseline frailty indicators in unselected patients (3) clarify the most relevant tools in predicting FR and clinical outcomes. This is a report of the study design and baseline patient evaluations. Materials & Methods: GOSAFE prospectively collected a baseline multidimensional evaluation before major elective surgery in patients (≥70 years) from 26 international units. Short−/mid−/long-term surgical outcomes were recorded with QoL and FR data. Results: 1003 patients were enrolled in a 26-month span. Complete baseline data were available for 977(97.4{\%}). Median age was 78 years (range 70–94); 52.8{\%} males. 968(99{\%}) lived at home, 51.6{\%} without caregiver. 54.4{\%} had ≥ 3 medications, 5.9{\%} none. Patients were dependent (ADL < 5) in 7.9{\%} of the cases. Frailty was either detected by G8 ≤ 14(68.4{\%}), fTRST ≥ 2(37.4{\%}), TUG > 20 s (5.2{\%}) or ASAIII-IV (48.8{\%}). Major comorbidities (CACI > 6) were detected in 36{\%}; 20.9{\%} of patients had cognitive impairment according to Mini-Cog. Conclusion: The GOSAFE showed that frailty is frequent in older patients undergoing cancer surgery. QoL and FR, for the first time, are going to be primary outcomes of a real-life observational study. The crucial role of frailty assessment is going to be addressed in the ability to predict postoperative outcomes and to correlate with QoL and FR.",
author = "{The SIOG surgical task force/ESSO GOSAFE study group} and Isacco Montroni and Siri Rostoft and Antonino Spinelli and {Van Leeuwen}, {Barbara L.} and Giorgio Ercolani and Saur, {Nicole M.} and Jacklitsh, {Michael T.} and Somasundar, {Ponnandai S.} and {de Liguori Carino}, Nicola and Federico Ghignone and Flavia Foca and Chiara Zingaretti and Audisio, {Riccardo A.} and Giampaolo Ugolini and Anna Garutti and Giovanni Taffurelli and Davide Zattoni and Paola Tramelli and Giacomo Sermonesi and {Di Candido}, Francesca and Michele Carvello and Matteo Sacchi and {De Lucia}, Francesca and Caterina Foppa and Matthijs Plas and {Van der Wal-Huisman}, Hanneke and Francesca Tauceri and Barbara Perenze and {Di Pietrantonio}, Daniela and Mariateresa Mirarchi and Michael Fejka and Bleier, {Joshua I.S.} and Laura Frain and Fox, {Sam W.} and Kristin Cardin and {De Leon}, {Luis E.} and Minas Baltatzis and Chan, {Anthony K.C.} and Siriwardena, {Ajith K.} and Bernadette Vertogen and Oriana Nanni and Gianluca Garulli and Vincenzo Alagna and Basilio Pirrera and Andrea Lucchi and Francesco Monari and {De Luca}, Raffaele and Michele Simone and Stefano Scabini and Davide Pertile and Andrea Massobrio and {De Cian}, Franco",
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TY - JOUR

T1 - GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery

T2 - early analysis on 977 patients

AU - The SIOG surgical task force/ESSO GOSAFE study group

AU - Montroni, Isacco

AU - Rostoft, Siri

AU - Spinelli, Antonino

AU - Van Leeuwen, Barbara L.

AU - Ercolani, Giorgio

AU - Saur, Nicole M.

AU - Jacklitsh, Michael T.

AU - Somasundar, Ponnandai S.

AU - de Liguori Carino, Nicola

AU - Ghignone, Federico

AU - Foca, Flavia

AU - Zingaretti, Chiara

AU - Audisio, Riccardo A.

AU - Ugolini, Giampaolo

AU - Garutti, Anna

AU - Taffurelli, Giovanni

AU - Zattoni, Davide

AU - Tramelli, Paola

AU - Sermonesi, Giacomo

AU - Di Candido, Francesca

AU - Carvello, Michele

AU - Sacchi, Matteo

AU - De Lucia, Francesca

AU - Foppa, Caterina

AU - Plas, Matthijs

AU - Van der Wal-Huisman, Hanneke

AU - Tauceri, Francesca

AU - Perenze, Barbara

AU - Di Pietrantonio, Daniela

AU - Mirarchi, Mariateresa

AU - Fejka, Michael

AU - Bleier, Joshua I.S.

AU - Frain, Laura

AU - Fox, Sam W.

AU - Cardin, Kristin

AU - De Leon, Luis E.

AU - Baltatzis, Minas

AU - Chan, Anthony K.C.

AU - Siriwardena, Ajith K.

AU - Vertogen, Bernadette

AU - Nanni, Oriana

AU - Garulli, Gianluca

AU - Alagna, Vincenzo

AU - Pirrera, Basilio

AU - Lucchi, Andrea

AU - Monari, Francesco

AU - De Luca, Raffaele

AU - Simone, Michele

AU - Scabini, Stefano

AU - Pertile, Davide

AU - Massobrio, Andrea

AU - De Cian, Franco

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Older patients with cancer value functional outcomes as much as survival, but surgical studies lack functional recovery (FR) data. The value of a standardized frailty assessment has been confirmed, yet it's infrequently utilized due to time restrictions into everyday practice. The multicenter GOSAFE study was designed to (1) evaluate the trajectory of patients' quality of life (QoL) after cancer surgery (2) assess baseline frailty indicators in unselected patients (3) clarify the most relevant tools in predicting FR and clinical outcomes. This is a report of the study design and baseline patient evaluations. Materials & Methods: GOSAFE prospectively collected a baseline multidimensional evaluation before major elective surgery in patients (≥70 years) from 26 international units. Short−/mid−/long-term surgical outcomes were recorded with QoL and FR data. Results: 1003 patients were enrolled in a 26-month span. Complete baseline data were available for 977(97.4%). Median age was 78 years (range 70–94); 52.8% males. 968(99%) lived at home, 51.6% without caregiver. 54.4% had ≥ 3 medications, 5.9% none. Patients were dependent (ADL < 5) in 7.9% of the cases. Frailty was either detected by G8 ≤ 14(68.4%), fTRST ≥ 2(37.4%), TUG > 20 s (5.2%) or ASAIII-IV (48.8%). Major comorbidities (CACI > 6) were detected in 36%; 20.9% of patients had cognitive impairment according to Mini-Cog. Conclusion: The GOSAFE showed that frailty is frequent in older patients undergoing cancer surgery. QoL and FR, for the first time, are going to be primary outcomes of a real-life observational study. The crucial role of frailty assessment is going to be addressed in the ability to predict postoperative outcomes and to correlate with QoL and FR.

AB - Objective: Older patients with cancer value functional outcomes as much as survival, but surgical studies lack functional recovery (FR) data. The value of a standardized frailty assessment has been confirmed, yet it's infrequently utilized due to time restrictions into everyday practice. The multicenter GOSAFE study was designed to (1) evaluate the trajectory of patients' quality of life (QoL) after cancer surgery (2) assess baseline frailty indicators in unselected patients (3) clarify the most relevant tools in predicting FR and clinical outcomes. This is a report of the study design and baseline patient evaluations. Materials & Methods: GOSAFE prospectively collected a baseline multidimensional evaluation before major elective surgery in patients (≥70 years) from 26 international units. Short−/mid−/long-term surgical outcomes were recorded with QoL and FR data. Results: 1003 patients were enrolled in a 26-month span. Complete baseline data were available for 977(97.4%). Median age was 78 years (range 70–94); 52.8% males. 968(99%) lived at home, 51.6% without caregiver. 54.4% had ≥ 3 medications, 5.9% none. Patients were dependent (ADL < 5) in 7.9% of the cases. Frailty was either detected by G8 ≤ 14(68.4%), fTRST ≥ 2(37.4%), TUG > 20 s (5.2%) or ASAIII-IV (48.8%). Major comorbidities (CACI > 6) were detected in 36%; 20.9% of patients had cognitive impairment according to Mini-Cog. Conclusion: The GOSAFE showed that frailty is frequent in older patients undergoing cancer surgery. QoL and FR, for the first time, are going to be primary outcomes of a real-life observational study. The crucial role of frailty assessment is going to be addressed in the ability to predict postoperative outcomes and to correlate with QoL and FR.

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JO - Journal of Geriatric Oncology

JF - Journal of Geriatric Oncology

SN - 1879-4068

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