Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: Results from the KING observational study of the Italian Society for Rheumatology (SIR)

Carlo A. Scirè, Maria Manara, Marco A. Cimmino, Marcello Govoni, Fausto Salaffi, Leonardo Punzi, Maria C. Monti, Greta Carrara, Carlomaurizio Montecucco, Marco Matucci-Cerinic, Giovanni Minisola, Alessandra Galossi, Ciro Lauriti, Elena Fracassi, Enrico Selvi, Enrico Tirri, Federica Furini, Flora Inverardi, Francesco Porta, Francesco VenturinoFranco Capsoni, Giandomenico Sebastiani, Gianluigi Fabbriciani, Giovanni D'Avola, Giulia Botticella, Giulia Seminara, Giuseppe D'Alessandro, Leonardo Santo, Lorena Longato, Luigi Sinigaglia, Marco Atteritano, Marco Broggini, Marta Caprioli, Marta Favero, Salvatore Sallì, Simone Parisi, Stefania Corvaglia, Vittorio Veneto

Research output: Contribution to journalArticle

Abstract

Introduction: Gout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases accounts for the increased disability or if gout may play a role by itself. This study aims to evaluate the specific influence of gout and disease-related features on functional disability and health-related quality of life (HRQoL) in patients with gout followed in rheumatology clinics.Methods: A random sample of patients was drawn from clinical registries of 30 rheumatology clinics across Italy. Sociodemographic, general health and gout-specific variables were collected. Functional disability and HRQoL were assessed by the health assessment questionnaire (HAQ) and the Physical and Mental Component Summary scores (PCS and MCS) of the Short Form-36 (SF-36). Crude and adjusted ordinal logistic and linear regression models were applied to investigate the specific contribution of different variables on HAQ and SF-36 scores. Results are presented as odds ratio (OR) or mean difference (MD) and 95% confidence intervals.Results: Out of 446 patients with gout, 90% were males with a mean age of 63.9 years and median disease duration of 3.8 years; the majority of patients were overweight or obese, and with several comorbidities; 21.1% showed at least moderate disability; the PCS score was significantly lower than expected age- and gender-matched samples in the general population, while MCS score was not. After adjusting for potential sociodemographic and general-health confounders, gout-specific variables significantly impacted on HAQ, including polyarticular involvement OR 3.82 (1.63, 8.95), presence of tophi OR 1.92 (1.07, 3.43) and recent attacks OR 2.20 (1.27, 3.81). Consistent results were found for PCS. The impairment of PCS compared to the general population was limited to patients with features of chronic gout. MCS was only affected by recent attacks (MD -2.72 [-4.58, -0.86]) and corticosteroid treatment (-3.39 [-5.30,-1.48]).Conclusions: The data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL. This result supports the need to improve specific treatment in gout.

Original languageEnglish
Article numberR101
JournalArthritis Research and Therapy
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 3 2013

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Gout
Rheumatology
Observational Studies
Quality of Life
Odds Ratio
Health
Linear Models
Italy
Population
Arthritis
Registries
Comorbidity
Adrenal Cortex Hormones
Logistic Models

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions : Results from the KING observational study of the Italian Society for Rheumatology (SIR). / Scirè, Carlo A.; Manara, Maria; Cimmino, Marco A.; Govoni, Marcello; Salaffi, Fausto; Punzi, Leonardo; Monti, Maria C.; Carrara, Greta; Montecucco, Carlomaurizio; Matucci-Cerinic, Marco; Minisola, Giovanni; Galossi, Alessandra; Lauriti, Ciro; Fracassi, Elena; Selvi, Enrico; Tirri, Enrico; Furini, Federica; Inverardi, Flora; Porta, Francesco; Venturino, Francesco; Capsoni, Franco; Sebastiani, Giandomenico; Fabbriciani, Gianluigi; D'Avola, Giovanni; Botticella, Giulia; Seminara, Giulia; D'Alessandro, Giuseppe; Santo, Leonardo; Longato, Lorena; Sinigaglia, Luigi; Atteritano, Marco; Broggini, Marco; Caprioli, Marta; Favero, Marta; Sallì, Salvatore; Parisi, Simone; Corvaglia, Stefania; Veneto, Vittorio.

In: Arthritis Research and Therapy, Vol. 15, No. 5, R101, 03.09.2013.

Research output: Contribution to journalArticle

Scirè, CA, Manara, M, Cimmino, MA, Govoni, M, Salaffi, F, Punzi, L, Monti, MC, Carrara, G, Montecucco, C, Matucci-Cerinic, M, Minisola, G, Galossi, A, Lauriti, C, Fracassi, E, Selvi, E, Tirri, E, Furini, F, Inverardi, F, Porta, F, Venturino, F, Capsoni, F, Sebastiani, G, Fabbriciani, G, D'Avola, G, Botticella, G, Seminara, G, D'Alessandro, G, Santo, L, Longato, L, Sinigaglia, L, Atteritano, M, Broggini, M, Caprioli, M, Favero, M, Sallì, S, Parisi, S, Corvaglia, S & Veneto, V 2013, 'Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: Results from the KING observational study of the Italian Society for Rheumatology (SIR)', Arthritis Research and Therapy, vol. 15, no. 5, R101. https://doi.org/10.1186/ar4281
Scirè, Carlo A. ; Manara, Maria ; Cimmino, Marco A. ; Govoni, Marcello ; Salaffi, Fausto ; Punzi, Leonardo ; Monti, Maria C. ; Carrara, Greta ; Montecucco, Carlomaurizio ; Matucci-Cerinic, Marco ; Minisola, Giovanni ; Galossi, Alessandra ; Lauriti, Ciro ; Fracassi, Elena ; Selvi, Enrico ; Tirri, Enrico ; Furini, Federica ; Inverardi, Flora ; Porta, Francesco ; Venturino, Francesco ; Capsoni, Franco ; Sebastiani, Giandomenico ; Fabbriciani, Gianluigi ; D'Avola, Giovanni ; Botticella, Giulia ; Seminara, Giulia ; D'Alessandro, Giuseppe ; Santo, Leonardo ; Longato, Lorena ; Sinigaglia, Luigi ; Atteritano, Marco ; Broggini, Marco ; Caprioli, Marta ; Favero, Marta ; Sallì, Salvatore ; Parisi, Simone ; Corvaglia, Stefania ; Veneto, Vittorio. / Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions : Results from the KING observational study of the Italian Society for Rheumatology (SIR). In: Arthritis Research and Therapy. 2013 ; Vol. 15, No. 5.
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abstract = "Introduction: Gout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases accounts for the increased disability or if gout may play a role by itself. This study aims to evaluate the specific influence of gout and disease-related features on functional disability and health-related quality of life (HRQoL) in patients with gout followed in rheumatology clinics.Methods: A random sample of patients was drawn from clinical registries of 30 rheumatology clinics across Italy. Sociodemographic, general health and gout-specific variables were collected. Functional disability and HRQoL were assessed by the health assessment questionnaire (HAQ) and the Physical and Mental Component Summary scores (PCS and MCS) of the Short Form-36 (SF-36). Crude and adjusted ordinal logistic and linear regression models were applied to investigate the specific contribution of different variables on HAQ and SF-36 scores. Results are presented as odds ratio (OR) or mean difference (MD) and 95{\%} confidence intervals.Results: Out of 446 patients with gout, 90{\%} were males with a mean age of 63.9 years and median disease duration of 3.8 years; the majority of patients were overweight or obese, and with several comorbidities; 21.1{\%} showed at least moderate disability; the PCS score was significantly lower than expected age- and gender-matched samples in the general population, while MCS score was not. After adjusting for potential sociodemographic and general-health confounders, gout-specific variables significantly impacted on HAQ, including polyarticular involvement OR 3.82 (1.63, 8.95), presence of tophi OR 1.92 (1.07, 3.43) and recent attacks OR 2.20 (1.27, 3.81). Consistent results were found for PCS. The impairment of PCS compared to the general population was limited to patients with features of chronic gout. MCS was only affected by recent attacks (MD -2.72 [-4.58, -0.86]) and corticosteroid treatment (-3.39 [-5.30,-1.48]).Conclusions: The data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL. This result supports the need to improve specific treatment in gout.",
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TY - JOUR

T1 - Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions

T2 - Results from the KING observational study of the Italian Society for Rheumatology (SIR)

AU - Scirè, Carlo A.

AU - Manara, Maria

AU - Cimmino, Marco A.

AU - Govoni, Marcello

AU - Salaffi, Fausto

AU - Punzi, Leonardo

AU - Monti, Maria C.

AU - Carrara, Greta

AU - Montecucco, Carlomaurizio

AU - Matucci-Cerinic, Marco

AU - Minisola, Giovanni

AU - Galossi, Alessandra

AU - Lauriti, Ciro

AU - Fracassi, Elena

AU - Selvi, Enrico

AU - Tirri, Enrico

AU - Furini, Federica

AU - Inverardi, Flora

AU - Porta, Francesco

AU - Venturino, Francesco

AU - Capsoni, Franco

AU - Sebastiani, Giandomenico

AU - Fabbriciani, Gianluigi

AU - D'Avola, Giovanni

AU - Botticella, Giulia

AU - Seminara, Giulia

AU - D'Alessandro, Giuseppe

AU - Santo, Leonardo

AU - Longato, Lorena

AU - Sinigaglia, Luigi

AU - Atteritano, Marco

AU - Broggini, Marco

AU - Caprioli, Marta

AU - Favero, Marta

AU - Sallì, Salvatore

AU - Parisi, Simone

AU - Corvaglia, Stefania

AU - Veneto, Vittorio

PY - 2013/9/3

Y1 - 2013/9/3

N2 - Introduction: Gout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases accounts for the increased disability or if gout may play a role by itself. This study aims to evaluate the specific influence of gout and disease-related features on functional disability and health-related quality of life (HRQoL) in patients with gout followed in rheumatology clinics.Methods: A random sample of patients was drawn from clinical registries of 30 rheumatology clinics across Italy. Sociodemographic, general health and gout-specific variables were collected. Functional disability and HRQoL were assessed by the health assessment questionnaire (HAQ) and the Physical and Mental Component Summary scores (PCS and MCS) of the Short Form-36 (SF-36). Crude and adjusted ordinal logistic and linear regression models were applied to investigate the specific contribution of different variables on HAQ and SF-36 scores. Results are presented as odds ratio (OR) or mean difference (MD) and 95% confidence intervals.Results: Out of 446 patients with gout, 90% were males with a mean age of 63.9 years and median disease duration of 3.8 years; the majority of patients were overweight or obese, and with several comorbidities; 21.1% showed at least moderate disability; the PCS score was significantly lower than expected age- and gender-matched samples in the general population, while MCS score was not. After adjusting for potential sociodemographic and general-health confounders, gout-specific variables significantly impacted on HAQ, including polyarticular involvement OR 3.82 (1.63, 8.95), presence of tophi OR 1.92 (1.07, 3.43) and recent attacks OR 2.20 (1.27, 3.81). Consistent results were found for PCS. The impairment of PCS compared to the general population was limited to patients with features of chronic gout. MCS was only affected by recent attacks (MD -2.72 [-4.58, -0.86]) and corticosteroid treatment (-3.39 [-5.30,-1.48]).Conclusions: The data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL. This result supports the need to improve specific treatment in gout.

AB - Introduction: Gout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases accounts for the increased disability or if gout may play a role by itself. This study aims to evaluate the specific influence of gout and disease-related features on functional disability and health-related quality of life (HRQoL) in patients with gout followed in rheumatology clinics.Methods: A random sample of patients was drawn from clinical registries of 30 rheumatology clinics across Italy. Sociodemographic, general health and gout-specific variables were collected. Functional disability and HRQoL were assessed by the health assessment questionnaire (HAQ) and the Physical and Mental Component Summary scores (PCS and MCS) of the Short Form-36 (SF-36). Crude and adjusted ordinal logistic and linear regression models were applied to investigate the specific contribution of different variables on HAQ and SF-36 scores. Results are presented as odds ratio (OR) or mean difference (MD) and 95% confidence intervals.Results: Out of 446 patients with gout, 90% were males with a mean age of 63.9 years and median disease duration of 3.8 years; the majority of patients were overweight or obese, and with several comorbidities; 21.1% showed at least moderate disability; the PCS score was significantly lower than expected age- and gender-matched samples in the general population, while MCS score was not. After adjusting for potential sociodemographic and general-health confounders, gout-specific variables significantly impacted on HAQ, including polyarticular involvement OR 3.82 (1.63, 8.95), presence of tophi OR 1.92 (1.07, 3.43) and recent attacks OR 2.20 (1.27, 3.81). Consistent results were found for PCS. The impairment of PCS compared to the general population was limited to patients with features of chronic gout. MCS was only affected by recent attacks (MD -2.72 [-4.58, -0.86]) and corticosteroid treatment (-3.39 [-5.30,-1.48]).Conclusions: The data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL. This result supports the need to improve specific treatment in gout.

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