GPI 6150, a poly (ADP-ribose) polymerase inhibitor, exhibits an anti-inflammatory effect in rat models of inflammation

Emanuela Mazzon, Ivana Serraino, Jia He Li, Laura Dugo, Achille P. Caputi, Jie Zhang, Salvatore Cuzzocrea

Research output: Contribution to journalArticle

Abstract

Poly (ADP-ribose) polymerase, a nuclear enzyme activated by DNA strand breaks, has been show to play an important role in the pathogenesis of inflammation. Here, we investigate the effects of GPI 6150 (1,11b-dihydro-[2H]benzopyrano [4,3,2-de]isoquinolin-3-one), a new poly (ADP-ribose) polymerase inhibitor, in animal models of acute and chronic inflammation (carrageenan-induced paw edema, adjuvant-induced arthritis and zymosan-induced multiple organ failure) where oxygen radicals, nitric oxide and peroxynitrite are known to play a crucial role in the inflammatory process. The results show that the poly (ADP-ribose) polymerase inhibitor GPI 6150 inhibits the inflammatory response (paw swelling, and organ injury). The present results demonstrate that inhibition of poly (ADP-ribose) polymerase by GPI 6150 exerts potent anti-inflammatory effects. Part of these anti-inflammatory effects may be related to a reduction of neutrophil recruitment into the inflammatory site.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalEuropean Journal of Pharmacology
Volume415
Issue number1
DOIs
Publication statusPublished - Mar 9 2001

Keywords

  • ADP-ribose
  • Anti-inflammatory
  • Polymerase

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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