GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues

E. Guerriero, F. Capone, M. Accardo, A. Sorice, M. Costantini, G. Colonna, G. Castello, Susan Costantini

Research output: Contribution to journalArticle

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is still one of the most fatal cancers. Hence, it needs to identify always new putative markers to improve its diagnosis and prognosis. The selenium is an essential trace mineral implicated as a key factor in the early stage of cancer and exerts its biological function through the selenoproteins. In the last years our group has been studying the involvement of some selenoproteins in HCC. However, no many data are reported in literature about the correlation between HCC and the glutathione peroxidases (GPXs), both selenium and non selenium-containing GPXs. In this paper we have evaluated the GPX4 and GPX7 expression in some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC by immunohistochemistry and RT-qPCR analysis. Our results evidenced that i) GPX4 and GPX7 had a statistically significant overexpression in HCC tissues compared to cirrhotic counterparts used as non tumor tissues, and ii) their expression was higher in grade III HCC tissues with respect to grade I-II samples. Therefore, we propose to use GPX4 and GPX7 as possible markers for improving HCC diagnosis/ prognosis.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalEuropean journal of histochemistry : EJH
Volume59
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • GPX4
  • GPX7
  • Hepatocellular carcinoma
  • Immunohistochemistry
  • RT-qPCR

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Biophysics

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  • Cite this

    Guerriero, E., Capone, F., Accardo, M., Sorice, A., Costantini, M., Colonna, G., Castello, G., & Costantini, S. (2015). GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues. European journal of histochemistry : EJH, 59(4), 5-10. https://doi.org/10.4081/ejh.2015.2540