Granin-derived peptides

J Troger, M Theurl, R Kirchmair, T Pasqua, B Tota, T Angelone, Maria Carmela Cerra, Y Nowosielski, R Mätzler, JR Gayen, V Trudeau, A Corti, KB Helle

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Abstract

The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980s it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance. The aim of this comprehensive overview is to provide an up-to-date insight into the distribution and properties of the well established granin-derived peptides and their putative roles in homeostatic regulations. Hence, focus is directed to peptides derived from the three main granins, e.g. to the chromogranin A derived vasostatins, betagranins, pancreastatin and catestatins, the chromogranin B-derived secretolytin and the secretogranin II-derived secretoneurin (SN). In addition, the distribution and properties of the chromogranin A-derived peptides prochromacin, chromofungin, WE14, parastatin, GE-25 and serpinins, the CgB-peptide PE-11 and the SgII-peptides EM66 and manserin will also be commented on. Finally, the opposing effects of the CgA-derived vasostatin-I and catestatin and the SgII-derived peptide SN on the integrity of the vasculature, myocardial contractility, angiogenesis in wound healing, inflammatory conditions and tumors will be discussed. © 2017 Elsevier Ltd
Original languageEnglish
Pages (from-to)37-61
Number of pages25
JournalProgress in Neurobiology
Volume154
Issue number1
DOIs
Publication statusPublished - 2017

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    Troger, J., Theurl, M., Kirchmair, R., Pasqua, T., Tota, B., Angelone, T., Cerra, M. C., Nowosielski, Y., Mätzler, R., Gayen, JR., Trudeau, V., Corti, A., & Helle, KB. (2017). Granin-derived peptides. Progress in Neurobiology, 154(1), 37-61. https://doi.org/10.1016/j.pneurobio.2017.04.003