Granisetron-dexamethasone combination for multiple day cisplatin

P. Pronzato, P. L. Losardo, F. Vaira, A. Vigani, M. Landucci, E. Ghio

Research output: Contribution to journalArticlepeer-review


Thirty-four patients being given polychemotherapy schedules including cisplatin at the dose of 20 mg/sm for 5 days entered an antiemetic protocol with granisetron and dexamethasone at the doses of 3 mg and 8 mg respectively, both administered i.v. before cisplatin. A complete response (no episodes of vomiting) and a major response (≤ 2 episodes of vomiting) were observed in 14 and 12 patients respectively; the toxicity of the antiemetics was mild. It is concluded that the granisetron dexamethasone combination is able to achieve a high rate of antiemetic control in the special set of multiple day cisplatin treated patients.

Original languageEnglish
Pages (from-to)2261-2263
Number of pages3
JournalAnticancer Research
Issue number5 B
Publication statusPublished - 1995


  • Cisplatin
  • Emesis
  • Granisetron

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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