Granisetron-dexamethasone combination for multiple day cisplatin

P. Pronzato, P. L. Losardo, F. Vaira, A. Vigani, M. Landucci, E. Ghio

Research output: Contribution to journalArticle

Abstract

Thirty-four patients being given polychemotherapy schedules including cisplatin at the dose of 20 mg/sm for 5 days entered an antiemetic protocol with granisetron and dexamethasone at the doses of 3 mg and 8 mg respectively, both administered i.v. before cisplatin. A complete response (no episodes of vomiting) and a major response (≤ 2 episodes of vomiting) were observed in 14 and 12 patients respectively; the toxicity of the antiemetics was mild. It is concluded that the granisetron dexamethasone combination is able to achieve a high rate of antiemetic control in the special set of multiple day cisplatin treated patients.

Original languageEnglish
Pages (from-to)2261-2263
Number of pages3
JournalAnticancer Research
Volume15
Issue number5 B
Publication statusPublished - 1995

Fingerprint

Granisetron
Antiemetics
Dexamethasone
Cisplatin
Vomiting
Combination Drug Therapy
Appointments and Schedules

Keywords

  • Cisplatin
  • Emesis
  • Granisetron

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pronzato, P., Losardo, P. L., Vaira, F., Vigani, A., Landucci, M., & Ghio, E. (1995). Granisetron-dexamethasone combination for multiple day cisplatin. Anticancer Research, 15(5 B), 2261-2263.

Granisetron-dexamethasone combination for multiple day cisplatin. / Pronzato, P.; Losardo, P. L.; Vaira, F.; Vigani, A.; Landucci, M.; Ghio, E.

In: Anticancer Research, Vol. 15, No. 5 B, 1995, p. 2261-2263.

Research output: Contribution to journalArticle

Pronzato, P, Losardo, PL, Vaira, F, Vigani, A, Landucci, M & Ghio, E 1995, 'Granisetron-dexamethasone combination for multiple day cisplatin', Anticancer Research, vol. 15, no. 5 B, pp. 2261-2263.
Pronzato P, Losardo PL, Vaira F, Vigani A, Landucci M, Ghio E. Granisetron-dexamethasone combination for multiple day cisplatin. Anticancer Research. 1995;15(5 B):2261-2263.
Pronzato, P. ; Losardo, P. L. ; Vaira, F. ; Vigani, A. ; Landucci, M. ; Ghio, E. / Granisetron-dexamethasone combination for multiple day cisplatin. In: Anticancer Research. 1995 ; Vol. 15, No. 5 B. pp. 2261-2263.
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