Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions

Cristiana Forni, Stefano Ferrari, Loretta Loro, Teresa Mazzei, Claudio Beghelli, Angela Biolchini, Patrizia Simoni, Morena Tremosini, Sergio Strazzari, Cristina Puggioli, Gaetano Bacci

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21 Citations (Scopus)

Abstract

The antiemetic efficacy of granisetron, ondansetron and tropisetron was evaluated in patients treated with cisplatin-Adriamycin (CDP/ADM) and ifosfamide (IFO) by continuous infusion (CI). In all, 90 patients with osteosarcoma were randomly assigned to receive granisetron (2 mg/m2), or ondansetron (5.3 mg/m2), or tropisetron (3.3 mg/m2) plus dexamethasone 8 mg/m2. Chemotherapy consisted of CDP (120 mg/m2, 48-h CI) followed by ADM (75 mg/m2, 24-h CI) and then, in the second cycle, delivered 3 weeks later, IFO 15 g/m2 (120-h CI). Complete protection (CP) from emesis was obtained on 59% of the 717 days of treatment, without significant differences among the three study drugs. A significantly higher rate of CP was obtained during chemotherapy with IFO than with CDP/ADM (69% vs 44%; P

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalSupportive Care in Cancer
Volume8
Issue number2
Publication statusPublished - Mar 2000

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tropisetron
Granisetron
Cytidine Diphosphate
Ondansetron
Ifosfamide
Doxorubicin
Cisplatin
Vomiting
Drug Therapy
Antiemetics
Osteosarcoma
Dexamethasone
Pharmaceutical Preparations

Keywords

  • Continuous infusion
  • Emesis
  • Granisetron
  • Ondansetron
  • Tropisetron

ASJC Scopus subject areas

  • Oncology
  • Nursing(all)

Cite this

Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions. / Forni, Cristiana; Ferrari, Stefano; Loro, Loretta; Mazzei, Teresa; Beghelli, Claudio; Biolchini, Angela; Simoni, Patrizia; Tremosini, Morena; Strazzari, Sergio; Puggioli, Cristina; Bacci, Gaetano.

In: Supportive Care in Cancer, Vol. 8, No. 2, 03.2000, p. 131-133.

Research output: Contribution to journalArticle

Forni, C, Ferrari, S, Loro, L, Mazzei, T, Beghelli, C, Biolchini, A, Simoni, P, Tremosini, M, Strazzari, S, Puggioli, C & Bacci, G 2000, 'Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions', Supportive Care in Cancer, vol. 8, no. 2, pp. 131-133.
Forni, Cristiana ; Ferrari, Stefano ; Loro, Loretta ; Mazzei, Teresa ; Beghelli, Claudio ; Biolchini, Angela ; Simoni, Patrizia ; Tremosini, Morena ; Strazzari, Sergio ; Puggioli, Cristina ; Bacci, Gaetano. / Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions. In: Supportive Care in Cancer. 2000 ; Vol. 8, No. 2. pp. 131-133.
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