Granulicatella bacteraemia in children: Two cases and review of the literature

Maia De Luca, Donato Amodio, Sara Chiurchiù, Maria A. Castelluzzo, Gabriele Rinelli, Paola Bernaschi, Francesca I. Calò Carducci, Patrizia D'Argenio

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Abstract

Background: Granulicatella spp. is a fastidious bacteria responsible for bacteremia and endocarditis which are fatal in about 20% of the cases. These severe infections are uncommon in children under 17 years of age and have proven extremely difficult to treat.Cases presentation: We report a brief review of the literature and two cases of NVS bacteremia by Granulicatella complicated by infective endocarditis (IE). The first one is that of a 7-year-old Caucasian female with Shone syndrome and IE involving the pulmonary valve homograft, confirmed by echocardiography. The second case is that of a 5-year-old Caucasian male. In this patient echocardiogram was negative for signs of IE; however, a " possible" IE was suspected on the basis of a cardiac catheterization 3 weeks before the onset of fever. Since in both our patients clinical failure of first line antibiotic treatment was observed, we used a combination of meropenem with another anti-streptococcal drug with excellent results.Conclusion: In Granulicatella bacteremia in the pediatric population, combination antimicrobial therapy including meropenem should be considered as a second line treatment in non-responding patients.

Original languageEnglish
Article number61
JournalBMC Pediatrics
Volume13
Issue number1
DOIs
Publication statusPublished - Apr 22 2013

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Keywords

  • Bacteremia
  • Endocarditis
  • Granulicatella
  • Meropenem
  • NVS
  • Paediatrics
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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