Granulocyte colony-stimulating factor: A novel mediator of T cell tolerance

Sergio Rutella, Flora Zavala, Silvio Danese, Hassen Kared, Giuseppe Leone

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, several investigators have unraveled a previously unrecognized role for G-CSF in the regulation of T cell and dendritic cell functions. The experimental evidence in favor of G-CSF-mediated immune regulation includes the ability to switch T cell cytokine secretion profile to Th2 responses and the promotion of regulatory T cell and tolerogenic dendritic cell differentiation. Interestingly, G-CSF is beneficial in animals for the prevention and/or treatment of immune-mediated diseases, e.g., graft-vs-host disease, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and diabetes, suggesting a potential role in human autoimmune diseases. This review summarizes the growing body of evidence that supports a critical role for G-CSF as a novel mediator of T cell tolerance.

Original languageEnglish
Pages (from-to)7085-7091
Number of pages7
JournalJournal of Immunology
Volume175
Issue number11
Publication statusPublished - Dec 1 2005

ASJC Scopus subject areas

  • Immunology

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