Granulocyte-colony stimulating factor and erythropoietin therapy in children with human immunodeficiency virus infection

G. V. Zuccotti, A. Plebani, G. Biasucci, M. Clerici-Schoeller, G. Banderali, S. Decahlis, R. Startari, E. Riva

Research output: Contribution to journalArticle

Abstract

To determine whether granulocyte-colony stimulating factor and erythropoietin are effective in the therapy of neutropenia and anaemia related to human immunodeficiency virus (HIV) infection and to anti-retroviral agents, we recruited 11 HIV-infected children (mean age 4 years 10 months). All the children were given granulocyte-colony stimulating factor at a dosage of 5 μg/kg twice or three times a week while erythropoietin was administered additionally to three patients at a dosage of 50 U/kg twice a week. Both agents were administered subcutaneously for at least 4 months. Leukocyte and neutrophil counts significantly increased during the treatment (after 1 month, P = 0.003 and P = 0.009, respectively). Erythropoietin prevented blood transfusions and increased haemoglobin levels in the three children treated. No side-effects were recorded during the administration of either agent. Granulocyte-colony stimulating factor and erythropoietin appear to be safe and useful agents in the management of HIV-infected children.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalJournal of International Medical Research
Volume24
Issue number1
Publication statusPublished - 1996

Keywords

  • Anaemia
  • Erythropoietin
  • Granulocyte-colony stimulating factor
  • Growth factors
  • HIV-infected children
  • Neutropenia

ASJC Scopus subject areas

  • Medicine(all)

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    Zuccotti, G. V., Plebani, A., Biasucci, G., Clerici-Schoeller, M., Banderali, G., Decahlis, S., Startari, R., & Riva, E. (1996). Granulocyte-colony stimulating factor and erythropoietin therapy in children with human immunodeficiency virus infection. Journal of International Medical Research, 24(1), 115-121.