Abstract
After several relapses, a stage IV lymphocyte depletion Hodgkin Lymphoma patient, with a bone marrow progenitor compartment depleted by several courses of chemotherapy, received further combination chemotherapy which caused severe and long-lasting pancytopenia. Because of an objective degree of tumor regression, a second identical course was administered, followed by Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) in an attempt to accelerate bone marrow recovery. This led to a significantly shorter period of neutropenia and thrombocytopenia with no additional red blood cell and platelet transfusion requirements. Furthermore, the neutropenic phase was not accompanied by septic complications. It is suggested that patients with solid tumors, even with a severely compromised bone marrow after several chemotherapy courses, may benefit from GM-CSF administration after rescue chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 61-66 |
| Number of pages | 6 |
| Journal | Leukemia and Lymphoma |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1990 |
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Keywords
- Chemotherapy
- GM-CSF
- Lymphoma
- Pancytopenia
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Granulocyte macrophage colony-stimulating factor (GM-CSF) reduces pancytopenia after rescue therapy in a patient with hodgkin's lymphoma. / Piacibello, Wanda; Camaschella, Clara; Stern, Angelika C.; Aglietta, Massimo.
In: Leukemia and Lymphoma, Vol. 3, No. 1, 1990, p. 61-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Granulocyte macrophage colony-stimulating factor (GM-CSF) reduces pancytopenia after rescue therapy in a patient with hodgkin's lymphoma
AU - Piacibello, Wanda
AU - Camaschella, Clara
AU - Stern, Angelika C.
AU - Aglietta, Massimo
PY - 1990
Y1 - 1990
N2 - After several relapses, a stage IV lymphocyte depletion Hodgkin Lymphoma patient, with a bone marrow progenitor compartment depleted by several courses of chemotherapy, received further combination chemotherapy which caused severe and long-lasting pancytopenia. Because of an objective degree of tumor regression, a second identical course was administered, followed by Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) in an attempt to accelerate bone marrow recovery. This led to a significantly shorter period of neutropenia and thrombocytopenia with no additional red blood cell and platelet transfusion requirements. Furthermore, the neutropenic phase was not accompanied by septic complications. It is suggested that patients with solid tumors, even with a severely compromised bone marrow after several chemotherapy courses, may benefit from GM-CSF administration after rescue chemotherapy.
AB - After several relapses, a stage IV lymphocyte depletion Hodgkin Lymphoma patient, with a bone marrow progenitor compartment depleted by several courses of chemotherapy, received further combination chemotherapy which caused severe and long-lasting pancytopenia. Because of an objective degree of tumor regression, a second identical course was administered, followed by Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) in an attempt to accelerate bone marrow recovery. This led to a significantly shorter period of neutropenia and thrombocytopenia with no additional red blood cell and platelet transfusion requirements. Furthermore, the neutropenic phase was not accompanied by septic complications. It is suggested that patients with solid tumors, even with a severely compromised bone marrow after several chemotherapy courses, may benefit from GM-CSF administration after rescue chemotherapy.
KW - Chemotherapy
KW - GM-CSF
KW - Lymphoma
KW - Pancytopenia
UR - http://www.scopus.com/inward/record.url?scp=0025552763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025552763&partnerID=8YFLogxK
U2 - 10.3109/10428199009050976
DO - 10.3109/10428199009050976
M3 - Article
AN - SCOPUS:0025552763
VL - 3
SP - 61
EP - 66
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 1
ER -