Granulocyte transfusions in children and adults with hematological malignancies: Benefits and controversies

Chiara Cugno, Sara Deola, Perla Filippini, David F. Stroncek, Sergio Rutella

Research output: Contribution to journalArticle

Abstract

Bacterial and fungal infections continue to pose a major clinical challenge in patients with prolonged severe neutropenia after chemotherapy or hematopoietic stem cell transplantation (HSCT). With the advent of granulocyte colony-stimulating factor (G-CSF) to mobilize neutrophils in healthy donors, granulocyte transfusions have been broadly used to prevent and/or treat life-threatening infections in patients with severe febrile neutropenia and/or neutrophil dysfunction. Although the results of randomized controlled trials are inconclusive, there are suggestions from pilot and retrospective studies that granulocyte transfusions may benefit selected categories of patients. We will critically appraise the evidence related to the use of therapeutic granulocyte transfusions in children and adults, highlighting current controversies in the field and discussing complementary approaches to modulate phagocyte function in the host.

Original languageEnglish
Article number362
JournalJournal of Translational Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - Nov 16 2015

Keywords

  • Dexamethasone
  • Febrile neutropenia
  • G-CSF
  • Granulocyte transfusion
  • Hematopoietic stem cell transplantation
  • Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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