Granuloma annulare following cryotherapy

R. Regazzini, C. Montemartini, R. Degiulio, D. Perini, C. De Filippi, M. Cespa, A. Donadini

Research output: Contribution to journalArticlepeer-review


Granuloma annulare (GA) is a benign dermatosis of unknown aetiology, characterized by papules with an annular disposition. Observation of the appearance of a GA in patients undergoing cryotherapy for common warts and actinic keratoses of the hands, led us to evaluate a possible relationship between the two conditions. Over 18 months we studied 158 patients treated with Liquid nitrogen and a compound based on formalin and resorcin for warts and actinic keratoses of the hands. After a year we observed GA in three women from group A who had undergone, respectively, six, five and seven applications of liquid nitrogen. There was also one woman from group C who developed GA after eight similar treatments. These observations suggested a possible correlation between the two events.

Original languageEnglish
Pages (from-to)41-42
Number of pages2
JournalJournal of Dermatological Treatment
Issue number1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Dermatology


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