Granuloma annulare with prominent lymphoid infiltrates (" pseudolymphomatous" granuloma annulare)

Carlo Cota, Gerardo Ferrara, Lorenzo Cerroni

Research output: Contribution to journalArticlepeer-review


Granuloma annulare (GA) is characterized histopathologically by 3 patterns: necrobiotic granuloma, interstitial incomplete form and, rarely, sarcoidal or tuberculoid granuloma. The amount of lymphoid infiltrate in GA is usually limited. We describe 10 cases of GA with prominent " pseudolymphomatous" lymphoid infiltrates mimicking cutaneous lymphoid hyperplasia. Patients were 6 males and 4 females (mean age 49.9 years, median age 47 years, age range 25-70). Lesions were localized to a limited area of the body (n = 6), or involved the entire trunk (n = 3), or were generalized (n = 1). The correct clinical diagnosis of GA was provided only in 30% of the cases. In all cases, histopathologic features were characterized by dense, nodular, superficial, and deep infiltrates of lymphocytes. Immunohistology revealed predominance of T lymphocytes in 7 of 7 tested cases. This " pseudolymphomatous" variant of GA represents a pitfall in the histopathologic diagnosis of the disease and may be misinterpreted as other types of cutaneous lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number3
Publication statusPublished - May 2012


  • Granuloma annulare
  • histopathologic variant
  • pseudolymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology


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