Granuloma faciale with extrafacial lesions.

Luigi Rossiello, Marco Palla, Francesco Saviero Aiello, Adone Baroni, Rocco Alfredo Satriano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 35-year-old man presented with a 7-year history of gradually enlarging plaques on his face and trunk. The first lesions had developed on both sides of the forehead and the left cheekbone (Figure 1). Four years later similar lesions appeared on his neck and back. He presented a histologic report of a biopsy specimen from a facial plaque performed 5 years earlier that was diagnostic for granuloma faciale. He had different treatments such as topical steroids and cryotherapy without improvement. The appearance of new lesions on his trunk and the gradual enlarging of the old lesions convinced the patient to seek further treatment. Physical examination revealed dusky, violaceous plaques and papules, 0.5 to 2 cm, well-circumscribed, slightly elevated, and located on the face and trunk, with mild pruritus (Figure 1 and Figure 2). Laboratory investigations, including complete blood cell count, VDRL test, antinuclear antibody test, biochemical parameters, and chest x-ray, did not reveal any abnormalities. A skin biopsy taken from the upper part of the back showed similar features to the facial lesion, detected 5 years before, revealing a dense, polymorphous infiltrate involving mid and deep dermis and displaying a diffuse and perivascular pattern (Figure 3A). A narrow grenz zone of normal collagen was consistently observed between dermal infiltrate and epidermis as well as around the pilosebaceous follicles (Figure 3A). The infiltrate mainly consisted of eosinophils and lymphocytes, but neutrophils (often displaying leukocytoclasis), macrophages, and plasma cells were also present (Figures 3B, 3C). Some mast cells were also identified by staining with toluidine blue (Figure 3D). Perivascular infiltrates were often seen, sometimes penetrating vessel walls and in association with leukocytoclasis. Hyalinization of vessel walls, extravasation of red blood cells around capillaries, and nuclear dust were also noted. The epidermis did not show any remarkable change except for slight acanthosis. A diagnosis of granuloma faciale with extrafacial lesions was made, and a systemic therapy with hydroxychloroquine (200 mg twice daily for 6 weeks) was recommended.(1,2).

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalSkinmed
Volume6
Issue number3
DOIs
Publication statusPublished - May 2007

Fingerprint

Granuloma
Blood Cell Count
Epidermis
Hydroxychloroquine
Biopsy
Tolonium Chloride
Skin
Cryotherapy
Forehead
Antinuclear Antibodies
Pruritus
Dermis
Plasma Cells
Dust
Eosinophils
Mast Cells
Physical Examination
Neutrophils
Neck
Collagen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rossiello, L., Palla, M., Aiello, F. S., Baroni, A., & Satriano, R. A. (2007). Granuloma faciale with extrafacial lesions. Skinmed, 6(3), 150-151. https://doi.org/10.1111/j.1540-9740.2007.05809.x

Granuloma faciale with extrafacial lesions. / Rossiello, Luigi; Palla, Marco; Aiello, Francesco Saviero; Baroni, Adone; Satriano, Rocco Alfredo.

In: Skinmed, Vol. 6, No. 3, 05.2007, p. 150-151.

Research output: Contribution to journalArticle

Rossiello, L, Palla, M, Aiello, FS, Baroni, A & Satriano, RA 2007, 'Granuloma faciale with extrafacial lesions.', Skinmed, vol. 6, no. 3, pp. 150-151. https://doi.org/10.1111/j.1540-9740.2007.05809.x
Rossiello L, Palla M, Aiello FS, Baroni A, Satriano RA. Granuloma faciale with extrafacial lesions. Skinmed. 2007 May;6(3):150-151. https://doi.org/10.1111/j.1540-9740.2007.05809.x
Rossiello, Luigi ; Palla, Marco ; Aiello, Francesco Saviero ; Baroni, Adone ; Satriano, Rocco Alfredo. / Granuloma faciale with extrafacial lesions. In: Skinmed. 2007 ; Vol. 6, No. 3. pp. 150-151.
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