Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse: A case report

Jennifer Vanoli, Marta Riva, Beatrice Vergnano, Gabriele D'Andrea, Vincenzo L'Imperio, Maria Rosa Pozzi, Guido Grassi

Research output: Contribution to journalArticle

Abstract

Rationale: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis affecting small- and medium-sized blood vessels, mostly involving lung and kidney. Patient concerns: We report the case of a 33-year-old man that presented with acute respiratory distress syndrome caused by alveolar hemorrhage. Diagnoses: Aggressive GPA presenting with diffuse alveolar hemorrhage and multiorgan involvement. Inteventions: Immunosuppressive therapy, plasma exchange, extracorporeal membrane oxygenation (ECMO). Outcomes: Relapse occurred very early, despite immunosuppressive treatment, with a rare involvement of genital system (epididymitis) and rapidly progressive glomerulonephritis difficult to treat. Lessons: GPA is a challenging, multifaceted disease that can require aggressive supportive therapy and is associated with a high rate of relapse that may present with uncommon site of involvement.

Original languageEnglish
Article numbere6024
JournalMedicine (United States)
Volume96
Issue number13
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Extracorporeal Membrane Oxygenation
Granulomatosis with Polyangiitis
Immunosuppressive Agents
Hemorrhage
Recurrence
Epididymitis
Plasma Exchange
Adult Respiratory Distress Syndrome
Glomerulonephritis
Vasculitis
Blood Vessels
Therapeutics
Kidney
Lung
Antibodies

Keywords

  • Case report
  • Diffuse alveolar hemorrhage
  • Extracorporeal membrane oxygenation
  • Granulomatosis with polyangiitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse : A case report. / Vanoli, Jennifer; Riva, Marta; Vergnano, Beatrice; D'Andrea, Gabriele; L'Imperio, Vincenzo; Pozzi, Maria Rosa; Grassi, Guido.

In: Medicine (United States), Vol. 96, No. 13, e6024, 01.01.2017.

Research output: Contribution to journalArticle

Vanoli, Jennifer ; Riva, Marta ; Vergnano, Beatrice ; D'Andrea, Gabriele ; L'Imperio, Vincenzo ; Pozzi, Maria Rosa ; Grassi, Guido. / Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse : A case report. In: Medicine (United States). 2017 ; Vol. 96, No. 13.
@article{a2fd4eab431e4961be9ed27730c38a54,
title = "Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse: A case report",
abstract = "Rationale: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis affecting small- and medium-sized blood vessels, mostly involving lung and kidney. Patient concerns: We report the case of a 33-year-old man that presented with acute respiratory distress syndrome caused by alveolar hemorrhage. Diagnoses: Aggressive GPA presenting with diffuse alveolar hemorrhage and multiorgan involvement. Inteventions: Immunosuppressive therapy, plasma exchange, extracorporeal membrane oxygenation (ECMO). Outcomes: Relapse occurred very early, despite immunosuppressive treatment, with a rare involvement of genital system (epididymitis) and rapidly progressive glomerulonephritis difficult to treat. Lessons: GPA is a challenging, multifaceted disease that can require aggressive supportive therapy and is associated with a high rate of relapse that may present with uncommon site of involvement.",
keywords = "Case report, Diffuse alveolar hemorrhage, Extracorporeal membrane oxygenation, Granulomatosis with polyangiitis",
author = "Jennifer Vanoli and Marta Riva and Beatrice Vergnano and Gabriele D'Andrea and Vincenzo L'Imperio and Pozzi, {Maria Rosa} and Guido Grassi",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/MD.0000000000006024",
language = "English",
volume = "96",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "13",

}

TY - JOUR

T1 - Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse

T2 - A case report

AU - Vanoli, Jennifer

AU - Riva, Marta

AU - Vergnano, Beatrice

AU - D'Andrea, Gabriele

AU - L'Imperio, Vincenzo

AU - Pozzi, Maria Rosa

AU - Grassi, Guido

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Rationale: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis affecting small- and medium-sized blood vessels, mostly involving lung and kidney. Patient concerns: We report the case of a 33-year-old man that presented with acute respiratory distress syndrome caused by alveolar hemorrhage. Diagnoses: Aggressive GPA presenting with diffuse alveolar hemorrhage and multiorgan involvement. Inteventions: Immunosuppressive therapy, plasma exchange, extracorporeal membrane oxygenation (ECMO). Outcomes: Relapse occurred very early, despite immunosuppressive treatment, with a rare involvement of genital system (epididymitis) and rapidly progressive glomerulonephritis difficult to treat. Lessons: GPA is a challenging, multifaceted disease that can require aggressive supportive therapy and is associated with a high rate of relapse that may present with uncommon site of involvement.

AB - Rationale: Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis affecting small- and medium-sized blood vessels, mostly involving lung and kidney. Patient concerns: We report the case of a 33-year-old man that presented with acute respiratory distress syndrome caused by alveolar hemorrhage. Diagnoses: Aggressive GPA presenting with diffuse alveolar hemorrhage and multiorgan involvement. Inteventions: Immunosuppressive therapy, plasma exchange, extracorporeal membrane oxygenation (ECMO). Outcomes: Relapse occurred very early, despite immunosuppressive treatment, with a rare involvement of genital system (epididymitis) and rapidly progressive glomerulonephritis difficult to treat. Lessons: GPA is a challenging, multifaceted disease that can require aggressive supportive therapy and is associated with a high rate of relapse that may present with uncommon site of involvement.

KW - Case report

KW - Diffuse alveolar hemorrhage

KW - Extracorporeal membrane oxygenation

KW - Granulomatosis with polyangiitis

UR - http://www.scopus.com/inward/record.url?scp=85016925082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016925082&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000006024

DO - 10.1097/MD.0000000000006024

M3 - Article

C2 - 28353556

AN - SCOPUS:85016925082

VL - 96

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 13

M1 - e6024

ER -