Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease

Giuliana Guggino; Valentina Orlando; Stella Cutrera; Marco P. La Manna; Diana Di Liberto; Valentina Vanini; Elisa Petruccioli; Francesco Dieli; Delia Goletti; Nadia Caccamo

doi:10.1016/j.imlet.2015.05.019

Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease

Giuliana Guggino, Valentina Orlando, Stella Cutrera, Marco P. La Manna, Diana Di Liberto, Valentina Vanini, Elisa Petruccioli, Francesco Dieli, Delia Goletti, Nadia Caccamo

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Immunology Letters
Volume	166
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2015.05.019
Publication status	Published - Aug 1 2015

Keywords

Disease
Granzyme A
IFN-γ
IGRA tests
Infection
Tuberculosis

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.imlet.2015.05.019

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Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease. / Guggino, Giuliana; Orlando, Valentina; Cutrera, Stella; La Manna, Marco P.; Di Liberto, Diana; Vanini, Valentina; Petruccioli, Elisa; Dieli, Francesco; Goletti, Delia; Caccamo, Nadia.

In: Immunology Letters, Vol. 166, No. 2, 01.08.2015, p. 87-91.

Research output: Contribution to journal › Article › peer-review

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title = "Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease",

abstract = "Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of ",

keywords = "Disease, Granzyme A, IFN-γ, IGRA tests, Infection, Tuberculosis",

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AU - Guggino, Giuliana

AU - Orlando, Valentina

AU - Cutrera, Stella

AU - La Manna, Marco P.

AU - Di Liberto, Diana

AU - Vanini, Valentina

AU - Petruccioli, Elisa

AU - Dieli, Francesco

AU - Goletti, Delia

AU - Caccamo, Nadia

PY - 2015/8/1

Y1 - 2015/8/1

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AB - Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of

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KW - IFN-γ

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Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease

Abstract

Keywords

ASJC Scopus subject areas

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