Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease

Giuliana Guggino, Valentina Orlando, Stella Cutrera, Marco P. La Manna, Diana Di Liberto, Valentina Vanini, Elisa Petruccioli, Francesco Dieli, Delia Goletti, Nadia Caccamo

Research output: Contribution to journalArticlepeer-review

Abstract

Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalImmunology Letters
Volume166
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Disease
  • Granzyme A
  • IFN-γ
  • IGRA tests
  • Infection
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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