Abstract
Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI).Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of
Original language | English |
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Pages (from-to) | 87-91 |
Number of pages | 5 |
Journal | Immunology Letters |
Volume | 166 |
Issue number | 2 |
DOIs | |
Publication status | Published - Aug 1 2015 |
Keywords
- Disease
- Granzyme A
- IFN-γ
- IGRA tests
- Infection
- Tuberculosis
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy