Graphene-based scaffolds for tissue engineering and photothermal therapy

Valentina Palmieri, Marco De Spirito, Massimiliano Papi

Research output: Contribution to journalArticlepeer-review

Abstract

Researchers have been creating 3D replicas of damaged tissues for millions of patients by using innovative biomaterials. While these scaffolds have regenerative properties, it would be beneficial if they could be utilized for local therapies, such as for cancer treatment. This report discusses the main advances in graphene scaffold design for near-infrared (NIR) photothermal therapy (PTT). NIR-PTT is a promising alternative for cancer cell killing, mediated by an increase of temperature due to NIR light-absorbers delivered to the tumor proximity. Graphene is a bidimensional material largely exploited in nanomedicine for its unique properties, such as high growth factor loading, which induces cell differentiation and its capacity to absorb NIR light. Here we cover aspects of future research in multifunctional graphene implants for cancer therapy and tissue regeneration.

Original languageEnglish
Pages (from-to)1411-1417
Number of pages7
JournalNanomedicine
Volume15
Issue number14
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • biopolymers
  • cancer/oncology
  • graphene
  • nanomaterials
  • nanotechnology
  • near-infrared
  • photothermal therapy
  • scaffold
  • targeted therapy
  • tissue engineering

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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